摘要
目的探讨CT引导放射性125I植入治疗纵隔淋巴结转移瘤的方法、安全性和临床疗效。方法对11例纵隔淋巴结转移瘤患者行CT引导下放射性125I粒子植入治疗,术前采用近距离治疗计划系统(TPS)制定计划,选择粒子活度:(1.11~2.96)×107Bq(0.3~0.8 m Ci),术后观察并发症发生情况,术后1、3、6、12个月评价肿瘤局部控制率、疼痛缓解有效率。结果术后出现气胸3例,气管瘘1例,肺部感染1例。随访1、3、6、12个月,患者局部控制率为81.8%、90.9%、72.7%、72.7%;疼痛缓解有效率,1周100%、1个月90.9%、3个月90.9%、6个月81.8%、12个月72.7%。结论 CT引导放射性125I粒子植入治疗纵隔转移瘤创伤小、并发症少、局部病灶控制率确切,是一种较为安全的治疗方法。
Objective To discuss the technical method, safety and clinical efficacy of CT-guided ^125I radioactive seed implantation for the treatment of mediastinal lymph node metastases. Methods CT- guided ^125I radioactive seed implantation was carried out in 11 patients with mediastinal lymph node metastases. Before ^125I seed implantation, the interstitial brachytherapy treatment planning system （TPS） was employed to formulate a treatment plan. The particles with radioactivity of （1.11-2.96） × 10^7Bq （0.3-0.8 mCi） were used for the implantation. Postoperative complications were recorded. The local lesion control rate and the effective rate of pain relief were evaluated at one, 3, 6 and 12 months after ^125I seed implantation. Results After ^125I seed implantation, pneumothorax occurred in 3 patients, tracheal fistula in one patient, and pulmonary infection in one patient. The local lesion control rates at one, 3, 6 and 12 months were 81.8%, 90.9%, 72.7% and 72.7% respectively; the effective rate of pain relief at one week, one, 3, 6 and 12 months were 100%, 90.9%, 90.9%, 81.8% and 72.7% respectively. Conclusion For the treatment of mediastinal lymph node metastases, CT-guided radioactive ^125I seed implantation is less-invasive with less complications, and it carries reliable local lesion control rate. Therefore, this technique is a safe therapeutic means.
作者
朱先海
王伟昱
秦汉林
施长杲
许军
谢韬
周磊
ZHU Xianhai WANG We@u QING Hanlin SHI Changgao XU Jun XIA Tao ZHOU Lei.(Department of lnterventional Oncology, Anhui Provincial Tumor Hospital, West Branch of Anhui Provincial Hospital, Hefei, Anhui Province 230061, China)
出处
《介入放射学杂志》
CSCD
北大核心
2017年第7期632-635,共4页
Journal of Interventional Radiology
