摘要
细胞-纳米药物递送系统作为一种新型的药物载体平台,通过将细胞或细胞膜覆盖在纳米药物表面得到,这种药物载体综合了纳米粒与细胞的特点。以细胞作为载体,极大地提高了药物的生物相容性和靶向性,降低了毒副作用,并延长了药物在体内的循环时间。而且,该载药系统还具有对肿瘤和炎症等病灶的主动趋向能力。因此其在药物转运、肿瘤放射治疗和疫苗制备等方面都有所应用。本文综述了以红细胞、单核巨噬细胞、肿瘤细胞及细菌细胞作为药物载体的最新进展。
Nanoparticles hold great potential in the improvement of the therapeutic activities of many drugs. Synthetic approaches are dominant in the conventional approach for nanoparticles design and engineering strategies. However, combination of synthetic nanoparticles with natural biomaterials have recently gained much attention. By taking inspiration from nature, cell-derived nanomedicine delivery system has been created, which is a biomimetic platform consisting of a nanoparticulate core coated with cell or cell membrane. Compared to the conventional drug delivery systems, this novel system combines the unique functionalities of cells and engineering versatility of synthetic nanomaterials for effective delivery of therapeutic agents. With existing of cell, nanomedicine has significantly improved the biocompatibility, accurate delivery and long half-life in circulation as well as reduced the toxicity and side effect of drugs. Moreover, the delivery system can interact with the incredibly complex biological systems that exist within the body, such as actively targeting the inflammatory sites and tumors. Hence, it can be applied to drug delivery, tumor radiotherapy, and vaccine preparation. The cell-derived nanomedicine delivery system emerging as a novel delivery strategy, have the potential to significantly advance the nanomedicine to improve the therapeutic efficacy. The recent research in characteristics, preparation and application of erythrocyte, mononuclear phagocyte, bacteria and tumor cell as nanomedicine delivery carrier are reviewed.
出处
《药学学报》
CAS
CSCD
北大核心
2017年第7期1110-1116,共7页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(21506192)
浙江省自然科学基金资助项目(LY16E030010)
关键词
细胞-纳米药物递送系统
细胞膜
纳米粒
红细胞
单核巨噬细胞系统
肿瘤细胞
细菌
cell-derived nanomedicine delivery system
cell membrane
nanoparticle
erythrocyte
mononuclear phagocyte system
tumor cell
bacteria
