摘要
目的探讨亚砷酸+全反式维甲酸联合高三尖杉酯碱(homoharringtonine,HHT)治疗急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)的疗效。方法选取自2006年1月~2013年1月本院初诊的APL患者,共124例,根据诱导分化治疗期间所用化疗药物的不同,分为两组,A组为观察组60例,采用亚砷酸+维甲酸联合HHT,B组为对照组64例,采用亚砷酸+维甲酸联合柔红霉素(daunorubicin,DNR)。结果 (1)A组诱导治疗期间白细胞高峰中位数低于B组,但差异无统计学意义(P>0.05);(2)A组、B组的CR率分别为91.67%、90.63%,两组比较无明显差异(P>0.05);(3)A组的不良反应及无复发生存期与B组比较差异无统计学意义(P>0.05)。结论 HHT与DNR相比,在治疗APL过程中,疗效与安全性较好,同时未影响完全缓解率,是较理想的治疗选择。
Objective To explore the curative effect of arsenite and all trans retinoic acid combined with homoharringtonine in treatment of acute promyelocytic leukemia. Methods Clinical data of 124 patients to our hospital for treatment of newly diagnosed acute promyelocytic leukemia from January 2006 to January 2013 were collected. According to the different chemotherapy drugs used in the treatment of induced differentiation, the patients were divided into two groups, 60 patients of group A for the observation group underwent ATO plus ATRA combined with HHT treatment; 64 patients of group B for the control group underwent ATO plus ATRA combined with DNR treatment. Results （1）In the group A, the median peak of white blood cell was lower than that of group B, but the difference between the two groups has no statistical significance; （2）The complete remission （CR） rate was 91.67% in group A and 90. 63% in group B, the difference was not statistically significant; （3）There was no significant difference in the adverse reaction and relapse free survival time between the group A and the group B （ P 〉 0. 05 ）. Conclusion Compared with HHT, DNR has better efficacy and safety in the treatment of APL, and it has no effect on the complete remission rate. It is an ideal treatment option.
出处
《哈尔滨医科大学学报》
CAS
2017年第2期153-155,共3页
Journal of Harbin Medical University
