摘要
目的通过对多烯磷脂酰胆碱不良反应的文献进行分析,为其更安全地应用于临床提供依据。方法在线检索万方、维普、知网、PubMed、Embase、Wiley、Springer、Cochrane等数据库,收集2010~2019年11月多烯磷脂酰胆碱不良反应的相关文献,对其进行统计分析。结果根据筛选和排除标准,最终纳入相关文献94篇,涉及6 611名患者,其中718名患者发生不良反应。常见不良反应为皮疹,恶心呕吐,腹泻腹胀,食欲不振等,多数经对症治疗后缓解或自行好转。结论多烯磷脂酰胆碱口服制剂的安全性较好,造成的不良反应较轻微,但注射剂的使用风险需加以关注。应加强对其不良反应的规范监测,确保其更加安全、合理的应用。
Objective To provide reference for safe use of polyene phosphatidyl-choline(PPC) in clinic by analyzing the literature about the adverse reactions of PPC. Methods Wanfang, Cqvip, CNKI, PubMed, Embase, Wiley, Springer, and Cochrane databases were searched online and the literature about adverse reactions(ADRs) caused by polyene phosphatidyl choline that was published between 2010 and 2019 was collected. Then, the data from the screened literature was analyzed. Results According to the screening criteria, 94 related articles were finally included involving a total of 718 subjects who had drug adverse reactions. The common adverse reactions of PPC were skin rash, nausea, vomiting, diarrhea, abdominal distension and loss of appetite. Most of the adverse reactions were relieved after symptomatic treatment or self-improved. Conclusion The oral preparations of PPC have proved to be safe and cause minor ADRs, but the risk posed by the injection deserves attention. Safe and rational application of PPC involves reinforcing standardized monitoring of PPC in the future.
作者
文晓玲
张海浪
WEN Xiaoling;ZHANG Hailang(Nanchong Center of Adverse Drug Reaction Monitoring,Nanchong Sichuan 637000,China)
出处
《中国药物警戒》
2020年第8期526-530,共5页
Chinese Journal of Pharmacovigilance
关键词
多烯磷脂酰胆碱
药品不良反应
胃肠道症状
皮疹
监测
polyene phosphatidyl choline
adverse reactions
gastrointestinal symptoms
skin rash
monitoring
