摘要
目的探讨受试者工作特征曲线(ROC)评价空腹血糖(FBG)和糖化血红蛋白(HbA1c)在诊断糖尿病视网膜病变(DR)中的价值。方法 600例糖尿病患者作为此次报告的研究对象,均进行FBG、HbA1c监测及眼底检查,从600例患者中随机抽取DR患者180例作为A组,视网膜正常患者182例作为B组,应用ROC曲线评价FBG、HbA1c对DR的评估风险。结果 A组FBG、HbA1c水平均高于B组,差异均具有统计学意义(P<0.05)。仅考虑FBG作用,FBG在7.9 mmol/L可以作为预防DR的安全参考值。单独考虑HbA1c作用,HbA1c控制在7.7%~8.2%可作预防DR的安全参考值。将FBG和HbA1c结合起来考虑,当HbA1c<9%时,FBG水平控制在8.2 mmol/L可作预防DR发生的安全参考值:当HbA1c≥9%时FBG水平控制在7.5 mmol/L可作为预防DR发生的安全参考值。结论 FBG联合HbA1c检测方法简便、快速、准确,且影响因素少,对DR筛查和预测性诊断具有重要意义,应将二者结合起来考虑,才能有效地预防DR的发生。
Objective To explore the value of receiver operating characteristic（ROC） curve for evaluating of fasting blood glucose（FBG） and glycosylated hemoglobin（HbA1c） in diagnosis of diabetic retinopathy（DR）. Methods A total of 600 diabetic patients as study subjects all received FBG and HbA1c monitoring and fundus examination. There were 180 DR patients as group A, and 182 normal retina patients as group B. ROC curve was applied to evaluate FBG and HbA1c for assessment risk of DR. Results Group A had higher FBG and HbA1c level than group B, and the difference had statistical significance（P〈0.05）. FBG as 7.9 mmol/L can be taken assecurity reference in prediction of DR by only considering effect of FBG, and HbA1c controlled 7.7%-8.2% can be taken as security reference in prediction of DR by only considering effect of HbA1c. By considering of FBG and HbA1c, FBG controlled as 8.2 mmol/L can be taken as security reference in prediction of DR when HbA1c〈9%, and FBG controlled as 7.5 mmol/L can be taken as security reference in prediction of DR when HbA1c ≥ 9%. Conclusion Combined detection of FBG and HbA1c is simple, rapid, accurate with few influence factors, and it is of great significance to DR screening and predictive diagnosis. Combining consideration can effectively prevent occurrence of DR.
出处
《中国实用医药》
2017年第16期48-50,共3页
China Practical Medicine
关键词
受试者工作特征曲线
血糖
糖化血红蛋白
糖尿病视网膜病变
风险评估
Receiver operating characteristic curve
Blood glucose
Glycosylated hemoglobin
Diabetic retinopathy
Risk assessment
