摘要
目的:探讨ROC曲线评价糖化血红蛋白在妊娠期糖尿病诊断中的临床价值。方法:选择孕妇240例,其中诊断妊娠期糖尿病者120例,血糖正常产妇120例,比较两组糖化血红蛋白与75g葡萄糖糖耐量试验水平,统计妊娠期糖尿病组不同糖化血红蛋白诊断界点与灵敏度、特异度之间的比较,并计算Youden指数。结果:正常组糖化血红蛋白及75g葡萄糖糖耐量试验结果均低于妊娠糖尿病组(P<0.05),Youden指数最高为0.418,相应的糖化血红蛋白诊断界点为5.65%,灵敏度为0.789,特异度为0.626,阳性预测值为0.869,阴性预测值为0.127。结论:由ROC曲线可知糖化血红蛋白诊断妊娠期糖尿病具有敏感性高、特异度强等特点,是一种快速、简便、准确确诊妊娠期糖尿病的方法。
Objective： To investigate the diagnosis value of ROC curve on the glycated hemoglobin with gestational diabetes. Method： 240 cases of pregnant women were selected and divided into the gastational diabetes group and normal blood glucose and euglycemia group,which 120 cases in each group,then glycated hemoglobin and 75 g glucose tolerance test levels in the two groups were compared,then different glycated hemoglobin diagnostic cutoff point and the sensitivity,specificity comparison in the gestational diabetes group were compared and Youden index wasculated. Result： The glycated hemoglobin and 75 g glucose tolerance test result in the normal blood glucose and euglycemia group were lower than those in the gestational diabetes group（ P〈0.05）,In which the Youden index was 0.418,correspond glycosylated hemoglobin diagnostic cutoff point was 5.65%,the sensitivity was 0.789,specificity was 0.626,the positive predictive was 0.869 and negative predictive value was 0.127. Conclusion： The ROC curve can show that glycated hemoglobin diagnosis on gestational diabetes has high sensitivity and specificity,so it is a fast,simple and accurate method for the diagnosis of gestational diabetes.
出处
《河北医学》
CAS
2016年第1期99-102,共4页
Hebei Medicine
基金
陕西省科技厅科技攻关项目
(编号:2013SFZ-06)
