摘要
DEAD-box RNA解旋酶是RNA解旋酶超家族成员之一,在细胞内该酶能水解NTP,与其他蛋白组成复合体发挥作用。它们参与核糖体、RNA或DNA结构的重塑,影响RNA的生成及RNA的多态性。目前,越来越多的研究表明,DEAD-box RNA解旋酶在肿瘤的发生、发展中起着重要作用;其表达水平与肿瘤的生长、转移及预后相关,并且表现出促癌和抑癌的双向作用。本文对目前关于DEAD-box RNA解旋酶与肿瘤关系的研究进展做一综述,讨论其参与肿瘤发生、发展的机制及对肿瘤预后及治疗的意义。
DEAD-box RNA helicases （DDX） are a member of RNA helicases superfamily ,they utilize energy derived from nucleotide triphospbate （NTP） hydrolysis and function as molecular complexes by interacting with other proteins in cell. DDX are implicated in remolding fibonucleoprotein complexes, RNA or DNA and in this manner affect the output and poly- morphism of RNA. Nowadays ,with an increasing number of researches, it has been identified that DDX are playing critical roles in tumorigenesis and tumor progression, their expression levels are related with tumor growth, metastasis and prognosis, besides, DDX are suggested to have both pro- and anti-proliferative roles in cancer. In this review, the research progress of relationship between DDX functions and neoplasm are reviewed to discuss the mechanism of DDX in tumor initiation, devel- opment and the significance of DDX in tumor prognosis and therapeutic.
作者
叶宏基
李少龙
安丽萍
周海宇
YE Hongji LI Shaoiong AN Liping ZHOU Haiyu(Department of Orthopaedics, Second Hospital of Lanzhou University, Lanzhou 730030, China Orthopaedics Key Laboratory of Gansu Province, Lanzhou 730030, China The People＇s Hospital of Dingxi,Dingxi 743000,China)
出处
《世界科技研究与发展》
CSCD
2017年第3期270-274,共5页
World Sci-Tech R&D
基金
国家自然科学基金(81560361)
甘肃省自然科学基金(1506RJZA201)
甘肃省骨关节疾病研究重点实验室开放课题(2012043007
2012043005)资助
