摘要
目的了解新疆乌鲁木齐地区某农牧区丙型肝炎病毒(HCV)的感染现状。方法选取2012年度乌鲁木齐地区某农牧区世居的农牧民,采取整群抽样,收集血清标本6 000人份。用于本次丙肝血清学检测标本5 025人份,有效标本5 005人份用于数据分析,采用ELISA方法对收集血清的抗-HCV进行检测,通过SAS9.2软件统计分析,以频数、构成比(%)、阳性率(%)进行统计描述,参照全国抗-HCV阳性率,评价新疆乌鲁木齐地区人群抗-HCV阳性率水平。使用卡方检验分析不同年龄、性别、民族人群抗-HCV阳性率的差异;使用Logistic回归分析性别、年龄及民族对抗-HCV阳性率的影响。结果乌鲁木齐地区男性抗-HCV阳性率为1.01%,女性抗-HCV阳性率为0.93%,男性和女性抗-HCV阳性率差异无统计学意义。不同性别各年龄组人群抗-HCV阳性率差异无统计学意义。汉族人群抗-HCV阳性率为1.05%,哈萨克族人群抗-HCV阳性率为0.63%,回族人群抗-HCV阳性率为0.76%,维吾尔族人群抗-HCV阳性率为1.00%,不同民族人群的抗-HCV阳性率差异无统计学意义。不同民族各年龄组人群抗-HCV阳性率差异有统计学意义。经Logistic回归分析,年龄和民族与抗-HCV阳性率无关。结论新疆乌鲁木齐地区某农牧区的HCV感染属中-低流行区,但是仍高于全国总体水平。
Objective To comprehend the infection status of hepatitis C virus （HCV） at an agricultural and pastoral zone in Urumqi area of Xinjiang. Methods Collected 6 000 serum samples of native farmers and herdsmen from the zone in 2012 by cluster sampling, and 5 025 serum samples were undergone anti HCV test with ELISA, in which 5 005 samples were effective. Statistical analysis was conducted by software of SAS9.2, describing with the frequency, the constituent ratio （%） , the positive rate （%） , and referring to the national anti-HCV positive rate to evaluate the rate in the zone. The difference of anti-HCV positive rate among different age, sex and nationality was analyzed by Chi square test, and the influence of gender, age and ethnicity on anti-HCV positive rate was analyzed by Logistic regression analysis. Results There was no significant difference between male and female in anti-HCV positive rate （1.01% vs 0.93%） in the zone, and no significant difference between age levels in different genders. Anti-HCV positive rate ofHAN, Kazakh, HUI and Uyghur population were 1.05%, 0.63%, 0.76% and 1 % respectively, which were no statistical significance among the ethnic groups. The difference of anti-HCV positive rate among age level groups in different ethnics was statistically significant. Concerning Logistic regression analysis, there was no correlation between age/ethnic and the anti-HCV positive rate. Conclusion HCV infection at an agricultural and pastoral zone in Urumqi area of Xinjiang is a low-mid endemic zone, but still higher than the national average.
出处
《新疆医科大学学报》
CAS
2017年第8期1088-1092,共5页
Journal of Xinjiang Medical University
基金
国际横向课题(ML29600)
