摘要
以靶向化疗为代表的靶向抗癌治疗已有数十年历史,但其实际结果远未达到预期,对其进行方法学上的哲学审视已经不容回避。靶向抗癌治疗以局部的分子或信号通路为靶点,存在着对致癌病因作用与靶点功能之间辩证关系认识不清,对癌细胞、肿瘤微环境和癌症患者等各个层次的整体性、基于整体的自稳性及自稳机制重视不够,以及对潜在靶点数量的相对无限性认识不足等问题。因此基于分析-还原思维背景的靶向治疗应该融入整体思维,并导归整合医学。
Because of targeting local moleeulars or signaling pathways, there are a series of issues in targeted anti-cancer therapy, such as no considering the dialectical relationship between cancer etiology and functions of targets, ignorance the integrity and its stabilizing mechanisms underlying on various levels including cancer cells, tumor microenvironment and cancer patients, and the relative limitlessness of potential targets number. Therefore, the analysis-reduction thinking mode of targeted therapy should be integrated into the integration thinking mode, and led to holistic integrated medicine.
出处
《医学与哲学（B）》
2017年第5期4-7,共4页
Medicine & Philosophy(B)
基金
2014年国家自然科学基金青年项目(81402063)
2014年绵阳市科技局科研项目(14s-01-3)
关键词
靶向治疗
癌症
哲学
targeted therapy, cancer, philosophy
