摘要
目的探讨序贯疗法与三联疗法根除幽门螺杆菌的临床疗效,并分析三联疗法与序贯疗法对反流性食管炎愈合率的影响。方法研究对象为我院2014年4月至2015年4月期间收治的120例反流性食管炎合并幽门螺杆菌感染患者,按不同治疗方法将其分为观察1组,观察2组以及对照3组,观察1组采用序贯疗法(埃索美拉唑+阿莫西林;埃索美拉唑+克拉霉素+替硝唑);观察2组给予三联疗法(埃索美拉唑+克拉霉素+阿莫西林);对照3组单独使用埃索美拉唑治疗。结果 120例患者中,92例患者彻底根除HP,在92例HP根除患者中,食管愈合79例,占85.87%,在28例HP根除失败或未根除的患者中,食管炎愈合26例,占92.86%,两者比较,差异无统计学意义(P>0.05);观察1组幽门螺杆菌根除率为90.00%,明显高于观察2组的77.50%(P<0.05)。结论针对反流性食管炎合并幽门螺杆菌感染的患者,序贯疗法的临床治疗效果显著优于单一的联合疗法,且对反流性食管炎的愈合率无明显影响。
Objective： To probe into the clinical effects of sequential therapy and triple therapy for eradication of helicobacter pylori,and to analyze the influencetriple therapy and sequential therapy in the treatment of reflux esophagitis healing rate. Methods： 120 patients with reflux esophagitis complicated with helicobacter pylori and who accepted treatments in our hospital from April,2014 to April,2015 were taken as the research objects,and the patients were divided into the observation group of 1 and the observation group of 2 and the control group of 3 according to different treatment methods. In the observation group of 1,the patients were treated with sequential therapy（ esomeprazole ＋ amoxicillin; esomeprazole ＋ clarithromycin and tinidazole）. In the observation group of 2,they were treated with triple therapy（ esomeprazole ＋ clarithromycin ＋amoxicillin） while in the control group of 3,they were only treated with the esomeprazole. Results： In the 120 cases of patients,HP were completely eradicated in 92 patients; In the 92 patients with eradication of HP,79 cases of esophageal were healed,and accounting for 85. 87%. In 28 patients with HP eradication failure or not eradicated,26 cases of esophageal inflammation were healed,accounting for 92. 86%,and there was no significant difference between the two groups（ P〉0. 05）; The eradication rate of helicobacter pylori in the observation group of 1 was 90%,which was significantly higher than that in the observation group of 2 of 77. 50%（ P〈0. 05）. Conclusion： According to the treatment of patients with reflux esophagitis complicated with Helicobacter pylori,the clinical treatment effect of sequential therapy is significantly better than that of single combination therapy,and there is no significant effect on the healing rate of reflux esophagitis.
作者
何海滨
HE Hai-bin(Heshan People＇s Hospital, Heshan 529700, Chin)
出处
《泰山医学院学报》
CAS
2016年第11期1248-1249,共2页
Journal of Taishan Medical College
关键词
序贯疗法
幽门螺杆菌
三联疗法
反流性食管炎
影响
sequential therapy
helicobacter pylori
triple therapy
reflux esophagitis
influence
