摘要
川崎病已逐渐代替风湿热成为儿童后天性心脏病的主要原因之一,但目前该病的发病诱因以及发病机制尚未明确。建立川崎病的动物模型可为找到川崎病的发病诱因及研究其发病机制提供重要实验基础。自川崎病发现以来,很多学者利用各种诱导剂,如白色念珠菌,干酪乳杆菌,牛血清,马血清等在动物中来诱导产生川崎病动物模型,其中小鼠为研究最多应用最广的动物模型,用这些模型进一步研究川崎病的发病诱因及其发病机制,并取得一定进展。本文将对现有川崎病动物模型及其相关的评价与应用作一综述。
Kawasaki disease has gradually replaced rheumatic fever became one of the major cause of acquired heart disease in children, but its etiology and pathogenesis has been unclear. However, animal model of Kawasaki disease has provided an important foundation of etiology and pathogenesis re-search. Since the Kawasaki disease discovered,Many scholars use kinds of inducers,such as Candida, Lactobacillus casei,bovine serum and horse serum injected to animals such as mice, rabbit dog and swine to build animal model of Kawasaki disease,and use these model for further study on etiology and pathogenesis of Kawasaki disease. This article summarize the existing animal model of Kawasaki disease and its associated evaluation and application.
出处
《内蒙古医科大学学报》
2016年第6期585-590,共6页
Journal of Inner Mongolia Medical University
基金
内蒙古科技厅科技计划项目(2014)
关键词
川崎病
动物模型
冠状动脉
kawasaki disease
animal model
coronary artery
