摘要
目的:探讨痰脂消颗粒联合二甲双胍改善肥胖型多囊卵巢综合征(PCOS)胰岛素抵抗的临床疗效。方法:选取2013年6月—2015年12月福建省妇幼保健院收治的PCOS胰岛素抵抗患者60例,按照随机数字表法分为两组,对照组30例患者给予二甲双胍口服(500 mg/次,3次/d)以及对症支持治疗,治疗组30例患者在对照组治疗的基础上加服痰脂消颗粒进行治疗。疗程均为3个月。观察并记录两组患者治疗前后的身高、体质量、腰围、中医症状积分、月经及妊娠情况以判定中医临床疗效;同时检测卵泡刺激素(FSH)、黄体生成素(LH)、催乳素(PRL),雌二醇(E_2)、睾酮(T)、甘油三酯(TG)、胆固醇(CHOL)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、糖耐量及糖负荷后的胰岛素释放试验,计算体质量指数、稳态模型评估的胰岛素抵抗指数(HOMA-IR)、糖耐量曲线下面积及胰岛素曲线下面积。结果:治疗组患者的临床显效率为82.8%,明显高于对照组的56%(P<0.05)。两组患者的BMI、腰围、LH、LH/FSH、T、HOMA-IR、CHOL、LDL、糖耐量曲线下面积及胰岛素曲线下面积均明显降低,与治疗前比较差异显著(P<0.05)。治疗组患者上述各指标降低程度较对照组更为明显(P<0.05)。结论:痰脂消颗粒联合二甲双胍治疗肥胖型PCOS临床效果良好,能显著改善胰岛素抵抗以及内分泌代谢紊乱,值得临床推广使用。
Objective： To investigate the clinical efficacy of Tanzhixiao Recipe combined with metformin in treatment of obese polycystic ovary syndrome with insulin resistance. Methods： Sixty cases of polycystic ovary syndrome with insulin resistance in our hospital from July 2013 to December 2015 were selected as the research objects and were divided into two groups according to the random number table method. Patients in control group（ 30 cases） were treated with metformin（ 500 mg·time^（-1）,3 time·d^（-1）） by orally taking and also with symptomatic and supportive treatment. Patients in treatment group（ 30 cases） were also given Tanzhixiao Recipe based on the treatment in control group. Treatment course was 3 months for both groups. Height,weight,waist circumference,TCM symptom score,menstruation and pregnancy in both groups were observed and recorded before and after treatment to determine the clinical efficacy of traditional Chinese medicine. In addition,follicle stimulating hormone（ FSH）,luteinizing hormone（ LH）,prolactin（ PRL）,estradiol（ E_2）,testosterone（ T）,triglyeride（ TG）,cholesterol（ Chol）,low density lipoprotein（ LDL）,high density lipoprotein（ HDL）,glucose tolerance and insulin release test after glucose load were detected before and after treatment and thenbody mass index（ BMI）,homeostasis model assessment of insulin resistance index（ HOMA-IR）,area under the curve of glucose tolerance and insulin were calculated. Result： The clinical effective rate was 82. 8% in treatment group,significantly higher than 56% in control group（ 0. 05）. Levels of BMI,waist circumference,LH,LH/FSH,T,HOMA-IR,CHOL,LDL,area under the curve of glucose tolerance and insulin were significantly decreased in both groups and had significant difference when compared with the conditions before treatment（ P〈0. 05）. Decrease degree in above indexes in treatment group was more significant than that in control group,with significant difference（ P〈0. 05）. Conclusion：Tanzhixiao Recipe combined with metformin in the treatment of obese PCOS has good clinical effect,significantly improves insulin resistance and disorders of endocrine and metabolism,worthy of clinical use.
出处
《中华中医药学刊》
CAS
北大核心
2017年第6期1431-1434,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81302998)
福建省科技计划项目(2015Y0002)
福建省中医药科研项目(wzfg201304)
福建省卫生计生委青年科研课题项目(2014-1-20)
