摘要
以4-氯甲基-2-喹啉酮为起始原料,通过与2-巯基苯甲腈的烷基化及Thorpe-Ziegler环化,得到4-(3-氨基苯并噻吩-2-基)-2-喹啉酮。接下来在对甲苯磺酸作用下,通过Pictet-Spengler反应与芳香醛进行缩合,合成了一系列苯并[b]苯并噻吩并[2’,3’-e][1,6]萘啶衍生物并获得较高的产率。产物经NMR、IR、元素分析数据证实。
An efficient method for the synthesis of benzo [ 6 ] benzothieno [ 2’,3,-e][1,6] naphthyridine derivatives had been devel-oped via Pictet-Spengler reaction of 4-（3-aminobenzothieno-2-yl） quinoline-2-ones,which could be obtained from S-alkylation and Thorpe-Ziegler isomerization of 4-chloromethylquinolin-2-ones with 2-mercaptobenzonitrile,with aromatic aldehydes under p-Ts0H as catalyst in good yields. All of above compounds had been confirmed by NMR,IR spectra and elemental analysis.
出处
《化学研究与应用》
CSCD
北大核心
2017年第5期721-726,共6页
Chemical Research and Application
