摘要
Enantioselective synthesis of functionalized fluorinated dihydropyrano[2,3-c]pyrazoles has been achieved via a diaminocyclohexane-thiourea catalyzed cascade Michael addition and Thorpe-Ziegler type cyclization in high yields （up to 98%） with moderate to good enantioselectivity （up to 90% ee）.
Enantioselective synthesis of functionalized fluorinated dihydropyrano[2,3-c]pyrazoles has been achieved via a diaminocyclohexane-thiourea catalyzed cascade Michael addition and Thorpe-Ziegler type cyclization in high yields （up to 98%） with moderate to good enantioselectivity （up to 90% ee）.
基金
supported by National Basic Research Program of China(973 Program,No.2010CB833200)
the National Natural Science Foundation of China(Nos.21032006,203900502,20532040,21290180)
Science and Technology Commission of Shanghai Municipality(No.11XD1406400)
