摘要
目的通过随机对照实验,观察四联菌片+莫沙比利片对LC术后消化功能紊乱的预防作用及疗效。方法将2015年1月-2016年1月入住我科的诊断为胆囊结石、胆囊良性息肉、胆囊结石并慢性胆囊炎及其他胆囊良性病变,需行腹腔镜胆囊切除术(LC)患者243例随机分为4组;A组(LC+术后常规治疗)61例,B组(LC+术后常规治疗+术后24h开始口服双歧杆菌四联菌素片3次/d,3粒/次,连续2周)61例,C组(LC+术后常规治疗+术后24h开始口服莫沙比利片3次/d,0.5mg/次,连续2周)61例,D组(LC+常规治疗+术后24h开始口服双歧杆菌四联菌素片3次/d,3粒/次,连续2周;口服莫沙比利片3次/d,0.5mg/次,连续2周)60例;观察腹痛、腹胀、反酸、嗳气、腹泻的发生情况及双歧杆菌四联菌素片同莫沙比利片对LC术后消化功能紊乱的治疗情况。结果相比于A组,其他组别消化功能紊乱的发生率明显较低(P<0.05),以D组的发生率最低(P<0.05)。各组Ⅱ级及以上症状发生占出现症状患者的比例无明显差异(P>0.05),经治疗后,绝大部分患者能缓解,各组间缓解率相比无明显差异(P>0.05)。结论四联菌片、莫沙比利片对LC术后消化功能紊乱的发生有预防作用,二者联合使用效果更明显;同时个体化治疗效果明显。
Objective To observe the preventive effect and effect of tetracycline and mosapride tablets on postoperative LC dyspepsia. Methods In January 2015-2016 January admitted to our diagnosis of gallbladder stones,gallbladder benign polyps, gallbladder stones and chronic cholecystitis,and other gallbladder benign lesions required laparoscopic cholecystectomy （LC） in 243 cases of patients with random points. Group A （LC ＋ postoperative conventional treatment） 61 cases,Group B （LC ＋ routine treatment ＋ 24 hours after the start of oral bifid bacterium tetracycline tablets three times a day,a three,for 2 weeks） 61 cases, Group C （LC ＋ conventional therapy ＋ postoperative 24 hours after oral administration of Mosapride tablets three times a day, a 0. 5rag,for 2 weeks） 61 cases,Group D （LC ＋ conventional therapy ＋ oral administration of bifid bacterium tetracycline tablets three times a day,once three times,for 2 weeks; oral Mosapride tablets a 24 hours after surgery Day three times,a 0.5mg, for 2 weeks） 60 cases;The incidence of abdominal pain, bloating, acid regurgitation ,belching and diarrhea were observed, and the treatment of Bifid bacterium tetracycline tablets and Mosapride tablets on the postoperative digestive disorders of LC. Results The incidence of dyspepsia was significantly lower in the other groups （P〈0.05） than in the A group,and the lowest in the D group （P〈0.05）. There was no significant difference in the proportion of patients with grade 11 and above symptoms（P〉0.05）;After treatment,the vast majority of patients can relieve the remission rate between the groups was no significant difference （P〉0.05）. Conclusion Tetramicin tablets and Mosapride tablets had a preventive effect on the occurrence of digestive disorders after LC,and the combined use of them was more obvious. Meanwhile,the effect of individual treatment was obvious.
作者
陈小平
盛维为
徐亦熊
沈伟
汪力
杨建设
CHEN Xi- aopin SHENG Weiwei XU Yixiong et al(Department of Surgery, Wuning County People＇s Jiangxi ,332300, Chin)
出处
《江西医药》
CAS
2017年第4期300-302,306,共4页
Jiangxi Medical Journal
