摘要
甲状腺未分化癌是一种恶性程度很高的肿瘤,区别于分化型甲状腺癌,常规的手术、放疗及化疗治疗效果较差。随着甲状腺未分化癌分子发病机制的不断研究,许多遗传学改变都被认为参与了甲状腺未分化癌发生、发展的过程,为甲状腺未分化癌的分子靶向治疗提供了新的可能。本文将介绍与甲状腺未分化癌发病相关的遗传学改变的研究进展,主要包括RAS/RAF/MAPK/ERK信号通路和PI3K/Akt m TOR信号通路。
As a highly malignant tumor,anaplastic thyroid carcinoma is different from differentiated thyroid cancer, conventional surgery,radiotherapy and chemotherapy can achieve poor results in the treatment of thyroid undifferentiated carcinoma.With the unceasing research on molecular pathogenesis of anaplastie thyroid carcinoma, many genetic changes are thought to be involved in the development process of anaplastic thyroid carcinoma and to provide a new possibility for molecular targeted treatment of thyroid undifferentiated carcinoma.In this paper, the research progress of the genetic changes related to the pathogenesis of anaplastic thyroid carcinoma is introduced, including RAS/RAF/MAPK/ERK signaling pathway and PI3K/Akt roTOR signaling pathway.
出处
《中国当代医药》
2017年第12期16-19,共4页
China Modern Medicine
关键词
甲状腺未分化癌
分子机制
基因
Anaplastic thyroid carcinoma
Molecular mechanism
Gene
