摘要
目的分析断流术和内镜下套扎术对肝硬化食管静脉曲张出血患者的疗效。方法随机选取2013年2月至2015年2月于本院治疗肝硬化食管静脉曲张出血的患者300例,其中采用食管胃静脉曲张断流术治疗的患者180例,采用内镜下套扎术治疗的患者120例。观察两组患者治疗1个月、6个月和1年后的肝功能变化、再出血率和病死率等。结果通过断流术治疗的患者术后1个月血清总胆红素(TBil)水平显著升高(t=3.32,P=0.021),最高达38 mg/L,血清白蛋白(ALB)水平显著降低。两组患者术后6个月及1年的TBil和ALB水平差异有统计学意义(P均<0.05)。通过断流术治疗的患者术后血小板(PLT)水平显著升高,且呈上升趋势,再出血率和病死率显著低于内镜下套扎术治疗的患者(P均<0.05)。结论断流术治疗的患者肝功能和血清白蛋白水平均有所改善,而内镜下套扎术治疗的患者无改善;断流术治疗的患者再出血率和病死率均显著低于内镜下套扎术治疗的患者。
Objective To analyze the effects of devascularization and endoscopic variceal ligation in treatment of patients with liver cirrhosis and esophageal variceal bleeding. Methods Total of 300 liver cirrhosis patients with esophageal variceal bleeding in our hospital from February 2013 to February 2015 were randomly selected,among whom 180 cases were given devascularization and 120 cases were given endoscopic variceal ligation.The liver function,rebleeding rate and fatality rate of the two groups were observed after treatment for 1 month,6 months and 1 year. Results The level of TBil in patients treated with devascularization increased significantly and the highest level was 38 mg/L （t = 3.32, P= 0.021）, while the level of ALB decreased. The level of TBil and ALB had statistical differences between the two groups （P 〈 0.05）. The levels of platelet （PLT） in patients treated with devascularization increased significantly and showed an increasing trend. The rate of rebleeding and mortality in patients treated with devascularization were significantly lower than those of patients treated with ndoscopic variceal ligation （P 〈 0.05）. Conclusions The liver function and ALB level had improvement in patients treated with devascularization and no improvement in patients treated with endoscopic variceal ligation.The rebleeding rate and fatality rate of patients treated with devascularization are significantly lower than those of patients treated with endoscopic variceal ligation.
出处
《中国肝脏病杂志（电子版）》
CAS
2017年第1期50-53,共4页
Chinese Journal of Liver Diseases：Electronic Version
