摘要
目的探讨红细胞分布宽度在冠状动脉扩张患者中的临床价值。方法研究对象为2014年6月至2016年5月期间本院收治的因胸痛疑诊冠心病或已明确冠心病行介入治疗,接受冠状动脉造影的患者,分为四组,A组60例为经CAG确诊为冠状动脉扩张的患者;B组80例为确诊为冠心病的患者;C组30例为既有冠状动脉扩张、又有冠心病的患者;D组60例为冠状动脉正常者。将A组患者再次分为两个亚组:轻中度冠状动脉扩张组50例,严重冠状动脉扩张组10例。结果 A组、B组、C组患者的吸烟史、糖尿病所占比例与D组比较更高,B组家族史患者所占比例与D组比较明显更高,差异有统计学意义(P<0.05)。A组、B组、C组IL-6、TNF-a、hs-CRP、Hcy、WBC、RDW与D组比较均明显更高,差异有统计学意义(P<0.05)。轻中度CAE组、重度CAE组IL-6、TNF-a、hs-CRP、Hcy、WBC、RDW与D组比较明显更高,差异有统计学意义(P<0.05);轻中度CAE组IL-6、TNF-a、hs-CRP、Hcy、WBC、RDW与重度CAE组比较明显更低,差异有统计学意义(P<0.05)。CAE的独立危险因素包括吸烟史、糖尿病、RDW、WBC、Hcy(P<0.05)。结论红细胞分布宽度与冠状动脉扩张相关,RDW增高则患者冠状动脉扩张程度增加,RDW的检测在冠状动脉扩张的诊断中具有较高的临床价值。
Objective To explore the clinical value of red blood cell distribution width in patients with coronary artery dilatation. Methods Subjects were divided into four groups by interventional treatment of coronary heart disease（ CHD） or coronary heart disease（ CHD） who had been diagnosed with chest pain or coronary artery disease from June 2014 to May 2016. They were divided into four groups. Group A（ n = 60）patients with coronary artery dilatation diagnosed by CAG,patients in group B（ n = 80） were confirmed as coronary heart disease; 30 patients in group C and patients with both coronary artery dilatation and coronary heart disease,and 60 patients in group D were coronary Arterial normal subjects. The patients in group A were divided into two subgroups： mild coronary artery dilation group（ n = 50） and severe coronary artery dilation group（ n =10）.Results The smoking history and the proportion of diabetes in group A,B and C were higher than those in group D,and the proportion of family history of group B was significantly higher than that of group D,the difference was statistically significant（ P〈0.05）. The levels of IL-6,TNF-a,hs-CRP,Hcy,WBC and RDW in group A,B and C were significantly higher than those in group D（ P〈0.05）. CRP,Hcy,WBC and RDW were significantly higher in CAE group than those in CAE group,and the difference was statistically significant（ P〈0.05）. In mild CAE group,the levels of IL-6,TNF-a,hs-CRP,Hcy,WBC and RDW were significantly lower than those in severe CAE group（ P〈0.05）. Independent risk factors for CAE included smoking history,diabetes mellitus,RDW,WBC,Hcy（ P〈0.05）.Conclusions The width of red blood cell distribution is correlated with coronary artery dilatation. Increased RDW can increase the extent of coronary artery dilatation. The detection of RDW has a high clinical value in the diagnosis of coronary artery dilatation.
出处
《齐齐哈尔医学院学报》
2017年第4期379-382,共4页
Journal of Qiqihar Medical University
基金
东莞市课题(2014105101167)
关键词
红细胞分布宽度
冠状动脉扩张
冠心病
Red blood cell distribution width
Coronary artery dilation
Coronary heart disease
