摘要
目的了解人类免疫缺陷病毒(HIV)/获得性免疫缺陷综合征(AIDS)感染者外周血指标、生化检测指标和免疫学指标特征,对临床检测和诊断HIV感染具有重要意义。方法用SPSS19.0软件对不同年龄段的外周血指标、生化检测指标和免疫学指标检测结果进行多组单因素方差分析,并描述异常率。结果外周血指标异常率:白细胞计数(WBC)18.22%、淋巴细胞(Ly)15.21%、血红蛋白(Hb)25.97%和血小板计数(PLT)14.49%。生化检测指标异常率:天门冬氨酸氨基转移酶(AST)4.16%、丙氨酸氨基转移酶(ALT)7.60%、肌酐(Cr)19.80%和尿素氮(BUN)15.49%。免疫学指标异常率:CD4^+71.02%、CD8^+64.42%、CD4^+/CD8^+36.01%。WBC、Ly、PLT、AST、ALT和CD4^+/CD8^+不同年龄段组间差异无统计学意义(P>0.05),Hb和BUN青年组与老年组组间差异有统计学意义(P<0.05),Cr、CD4^+和CD8^+在青年组与中年组、青年与老年组组间差异有统计学意义(P<0.05)。结论 CD4^+细胞计数作为检测HIV/AIDS感染者的主要指标,结合CD8^+细胞数和CD4^+/CD8^+值,具有一定的敏感性,根据CD4^+细胞数发现并筛选HIV/AIDS感染者,不同年龄段应设定不同的参考范围。
Objective To know the characteristics of peripheral blood indexes,biochemical testing indexes and immunological indexes in HIV/AIDS patients,which have an important significance to clinical detection and diagnosis of HIV infection.Methods The SPSS19.0software was used to conduct the multigroup single factor analysis of variance and describe the abnormal rate for the detection results of peripheral blood indexes,biochemical indexes and immunological indexes in different age groups.Results Theperipheral blood indices abnormal rate：WBC 18.22%,lymphocyte（Ly）15.21%,hemoglobin（Hb）25.97% and platelet（PLT）14.49%.The biochemical detection indices abnormal rate：AST 4.16%,ALT 7.60%,Cr 19.80%and BUN 15.49%.The abnormal immunological indexes rate：CD4^＋71.02%,CD8^＋64.42%,CD4^＋/CD8^＋36.01%.There was no statistically significant difference in WBC,Ly,PLT,AST,ALT,and CD4^＋/CD8^＋among the different age groups（P〈0.05）,Hb and BUN had statistical difference between the youth group and old age group（P〈0.05）.Cr,CD4^＋and CD8^＋had statistical difference between the youth group and middle-aged group and between the youth group and old age group were statistically significant difference between the groups（P〈0.05）.Conclusion CD4^＋cell count as the main indicator of detecting HIV/AIDS infected people combined with the CD8^＋cells count and CD4^＋/CD8^＋values has a certain sensitivity,the HIV/AIDS infected people are found and screened according to the CD4^＋cells count,the different reference ranges in different age groups should be set.
出处
《检验医学与临床》
CAS
2017年第8期1047-1048,1051,共3页
Laboratory Medicine and Clinic
基金
国家自然科学基金资助项目(81303149)
中央级公益性科研院所专项资金资助项目(ZZ070818)
湖北省厅级重点资助项目(d20152003)
