摘要
目的探讨血清甲状腺激素、甲状腺转录因子-1(TTF-1)与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的相关性。方法回顾性分析2015年1月至12月在新疆维吾尔自治区人民医院高血压中心就诊的262例可疑OSAHS患者的临床资料。所有患者行多导睡眠(PSG)监测,根据呼吸暂停低通气指数(AHI)分为对照组(n=110)、轻度OSAHS组(n=56)、中度OSAHS组(n=47)和重度OSAHS组(n=49)。检测对照组和重度OSAHS组TTF-1水平,以及四组患者甲状腺功能5项;并分析其与OSAHS的相关性。结果四组患者在性别、饮酒率、腹围、体质指数(BMI)、高密度脂蛋白胆固醇(HDL-C)和甘油三酯的比较上,差异均有统计学意义(P均<0.01)。对照组与重度OSAHS组患者的TTF-1水平无明显差异(P>0.05);游离甲状腺素(FT4)水平在四组患者间差异有统计学意义(P<0.01),其中重度OSAHS组FT4水平较对照组、轻度OSAHS组和中度OSAHS组均明显升高(P均<0.05)。多元线性回归分析显示,男性、高BMI和高AHI可能是影响OSAHS患者FT4水平的危险因素(P<0.01,P<0.05)。结论 TTF-1不能作为OSAHS的潜在生物标志物。OSAHS可引起FT4的异常分泌,性别、BMI和AHI可能是OSAHS患者FT4水平变化的影响因素,推测OSAHS可能与甲状腺疾病存在一定的相关性。
Objective To investigate the relationship between serum thyroid hormones, thyroid transcription factor-1 （ TTF- 1 ） and obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods Retrospective analysis was performed on the clinical data of 262 suspected OSAHS patients who visited the Hypertension Center in Xinjiang Uygur Autonomous Region People＇s Hospital between January 2015 and December 2015. Polysomnography （PSG） detection was performed in all pa- tients. The patients were divided into control group （ n = 110 ）, mild-（ n = 56 ）, moderate-（ n = 47 ） and severe-（ n = 49 ） OSAHS groups according to apnea hypopnea index （AHI）. TTF-1 levels in control group and severe-OSAHS group and five thyroid functions in four groups were detected, and the correlation between them and OSAHS was analyzed. Results There were significant differences in sex,drinking rate, abdominal circumference, body mass index （BMI）, high density lipopro- tein cholesterol （ HDL-C ） and triglyeeride （TG） in four groups （ all P 〈 0.01 ）. The TTF-1 levels were similar between con- trol group and severe-OSAHS group （ P 〉 O. 05 ）. There was significant difference in free thyroxine （ FT4 ） levels of four groups （P 〈 0.01 ） , in wich FT4 level of severe-OSAHS group was significantly higher than those of other three groups （ all P 〈 0.05 ）. Multiple linear regression analysis showed that male, high BMI and large AHI may be the risk factors influen- cing FF4 level of OSAHS patients （ P 〈 0.01 or P 〈 0.05 ）. Conclusions TTF-1 cannot be served as a potential biomarker of OSAHS. OSAHS can cause abnormal secretion of FT4, thus it is speculated that OSAHS may be associated with thyroid diseases. Sex, BMI and AHI may be the risk factors influencing FT4 level of OSAHS patients.
出处
《中国临床研究》
CAS
2017年第4期433-436,共4页
Chinese Journal of Clinical Research
基金
新疆自治区卫生厅青年科技人才专项(2015Y20)
新疆医科大学研究生创新项目(CXCY47)
