摘要
阻塞性睡眠呼吸暂停低通气综合征（Obstruetive Sleep Apnea—Hyperpnoea Syndrome，OSAHS）是一种具有潜在危险的疾病。它以睡眠时频繁的呼吸浅慢、暂停，反复发生低通气、血氧饱和度（SaO2）下降为特征，常导致全身多器官功能损害，尤因易并发心血管系统疾病而引起人们高度重视。近年研究发现间接胆红素（I-BIL）具有抗氧化和抗动脉粥样硬化的功能。
Objective: To examine the levels of indirect bilirubin and uric acid in patients with Obstructive sleep apnea-hyperpnoea syndrome (OSAHS), and to investigate the role of indirect bilirubin and uric acid played in the process of OSAHS with cardiovascular disease. Method: OSAHS patients and healthy people were monitored using polysomongraphy. About 4 ml fasting venous blood was collected. Fasting serum indirect bilirubin and uric acid levels were measured in OSAHS patients and healthy people. Results: The levels of indirect bilirubin were 14.53±3.64 μmol/L in healthy people. Indirect bilirubin levels were lower in mild, midrange and severe OSAHS patients than that in healthy people(P<0.05~0.01),and the levels of uric acid were 252.05±75.64 μmol/L in healthy people. Uric acid levels were higher in mild, midrange and severe OSAHS patients than that in healthy people(P<0.05~0.01).Correlation analysis suggested that there was a negative correlation between indirect bilirubin and AHI(r=-0.32,P<0.01)) and a negative correlation between minimum saturation of blood oxygen and AHI(r=-0.56,P<0.01), a positive correlation between uric acid and AHI(r=0.27,P<0.05). Conclusion: The level of indirect bilirubin in patients with Obstructive sleep apnea-hyperpnoea syndrome (OSAHS) was lower than that of healthy group, and uric acid level in OSAHS patients was higher than that of healthy group. This could be one of the important mechanisms for the processing of hypertension and coronary artery diseases in OSAHS patients.
出处
《微循环学杂志》
2007年第2期35-36,38,共3页
Chinese Journal of Microcirculation
