摘要
目的探讨鼻咽癌组织中蛋白磷酸酶2A的癌性抑制因子(CIP2A)与c-Myc表达及其临床意义。方法应用免疫组织化学染色技术检测68例鼻咽癌组织(鼻咽癌组)和20例鼻咽黏膜慢性炎组织(对照组)CIP2A、c-Myc蛋白的表达,分析CIP2A、c-Myc与鼻咽癌临床病理特征的关系。结果鼻咽癌组的CIP2A和c-Myc阳性表达率分别为54.4%(37/68)、66.2%(45/68),均高于对照组的15.0%(3/20)、25.0%(5/20)(P<0.05)。CIP2A和c-Myc蛋白阳性表达与鼻咽癌患者性别、年龄、临床分期、肿瘤大小以及有无淋巴结转移无关(P>0.05)。鼻咽癌组织中CIP2A与c-Myc蛋白表达呈正相关(P<0.05)。结论 CIP2A和c-Myc在鼻咽癌组织中表达均升高,可能共同参与鼻咽癌的发生发展过程。
Objective To investigate the expressions and clinical significance of cancerous inhibitor of protein phosphatase 2A （CIP2A） and c-Myc in nasopharyngeal carcinoma tissues. Methods Immunohistochemistry staining was used to detect the CIP2A and e-Myc expressions in 68 samples of nasopharyngeal carcinoma tissues （nasopharyngeal carcinoma group） and 20 samples of chronic inflammatory tissues of nasopharyngeal mucosa（ control group）. The relationship of CIP2A and c-Myc with clinicopathological features of nasopharyngeal carcinoma was analyzed. Results The positive expression rates of CIP2A and c-Myc in the nasopharyngeal carcinoma group were 54.4% （37/68） and 66.2% （45/68） respectively,were higher than those in the control group[ 15.0% （3/20） ,25.0% （5/20） respectively] （P 〈 0.05 ）. The positive protein expressions of CIP2A and c-Myc in the nasopharyngeal carcinoma tissues did not correlate with gender, age, clinical stage, tumor size or lymph node metastasis （P 〉 0.05 ）. The protein expression of CIP2A positively correlated with the protein expression of c-Myc in nasopharyngeal carcinoma （ P 〈 0.05 ）. Conclusion Up-regulated expressions of both CIP2A and c-Myc can be observed nasopharyngeal carcinorna tissues, and both of them might involve in the occurrence and development of nasopharyngeal carcinoma.
出处
《广西医学》
CAS
2017年第4期457-459,共3页
Guangxi Medical Journal
基金
广西南宁市科学研究与技术开发计划(20133182)
广西医药卫生科研课题(Z2014458)
