摘要
神经调节蛋白-1(NRG-1)可以通过旁分泌和自分泌的方式与其酪氨酸激酶受体结合,激活下游通路发挥一系列生物反应,还可以通过抑制交感神经兴奋来降低压力负荷从而改善心功能。最近研究发现NRG-1对多功能干细胞分化有诱导作用;临床试验证实人类重组NRG-1可以降低N末端B型利钠肽前体(NT-proBNP)、再入院率和心衰发作次数。本文就NRG-1在心血管疾病领域的研究进展作一综述。
Neuregulin-1（NRG-1）can bind with its tyrosine kinase receptor via paracrine and autocrine,activate downstream pathways and perform a series of biological reactions,and reduce pressure load and improve heart function through inhibiting sympathetic nerve excitement.Recent study identified that NRG-1 can induce pluripotent stem cell differentiation;clinical trials proved that recombinant human NRG-1 can reduce level of N terminal pro brain natriuretic peptide,rehospitalization rate and onset times of heart failure.The present article made a review on research progress of NRG-1 in cardiovascular field.
出处
《心血管康复医学杂志》
CAS
2017年第2期228-230,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
邯郸市科技局科学技术研究与发展计划项目基金资助(1223108088-5)~~
