摘要
目的:探讨氨基末端脑钠素前体(NT-proBNP)水平对慢性心力衰竭患者病情评估的临床价值。方法:选择慢性心力衰竭患者135例,以NYHA方法评估其心功能,部分患者行超声心动图检查测定左室射血分数(LVEF);采用ELISA法测定NT-proBNP水平,放射免疫法测定肾素-血管紧张素-醛固酮系统激素水平。结果:随着心功能级别增高,NT-proBNP水平递增,Ⅰ级(1例)、Ⅱ级(47例)、Ⅲ级(65例)和Ⅳ级(22例)的NT-proB-NP水平分别为61、746、1668和4720ng/L。各级间均差异有统计学意义(P<0·01)。血管紧张素原、肾素、血管紧张素Ⅱ及醛固酮的血浆水平,随心功能或LVEF变化不显著或无规律性。结论:NT-proBNP水平对于慢性心力衰竭患者的病情评估具有较高的价值,且优于肾素-血管紧张素-醛固酮系统激素。
Objective：To evaluate the levels of NT-proBNP and its clinical value in patients with chronic left heart failure （CHF） with different NYHA class. Method.. Patients （aged 18-80 years） with chronic left heart failure were included in this study , who were from the Dept. of inpatient , emergence room or outpatient in our hospital. Plasma concentrations of the N-terminal portion of brain natriuretic （NT-proBNP）, rennin activity （PRA）, angiotensin Ⅱ （AT Ⅱ ） and aldosterone（Aldo） were detected by ELISA or RIA assay. Result： One hundred and thirty-five patients with chronic left heart failure were included in this study. The median levels of NT- proBNP increased gradually in 135 patients with chronic left heart failure, which associated with NYHA heart function classes increased by degrees; that was, M value of NT proBNP was 61 ng/L in NYHA class Ⅰ （ n =1）, 746 ng/L in class Ⅱ （ n =47）, 1668 ng/L in class Ⅲ （ n =65）, and 4720 ng/L in class Ⅳ group （ n =22）. They were different statistics significantly among different classes. While there were theincreasing trend of NT- proBNP levels associated with the decreasing of left ventricular ejection fraction （LVEF） by echocardiography in 88 cases from above 135 cases （ P〉0.05）, but the levels of AO, PRA, ATⅡ and Aldo had no significant association with NYHA classes or LVEF. Conclusion：The levels of NT-proBNP in patients with chronic left heart failure can assess disease severity, which maybe superior to RAAS hormones.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2006年第7期407-409,共3页
Journal of Clinical Cardiology
基金
国家863计划"十五"重大科技专项"药物临床试验关键技术平台研究"课题(No:2002AA2Z341A)
