摘要
目的探讨低频重复经颅磁刺激（rTMs）治疗首发青少年抑郁症的疗效及安全性。方法将30例首发未用药的青少年抑郁症患者随机分为rTMS组和对照组各15例，均不采用药物治疗。rTMS组采用低频rTMS刺激右侧额叶背外侧皮质（DLPFC），对照组采用假性刺激，每周治疗5次，连续治疗2周。采用汉密尔顿抑郁量表24项（HAMD。）评估治疗前后的疗效。结果（1）rTMS组有效率100％，对照组有效率0％，两组差异有统计学意义（P〈0．01）。（2）治疗后rTMS组HAMD2。总分及因子分均较基线期显著下降（P〈0．05），对照组HAMD。总分及因子分较基线期无明显变化（P〉0．05）。（3）rTMS组和对照组的不良反应发生率差异无统计学意义（P〉0．05），两组均未出现严重不良反应。结论低频rTMS可有效改善首发青少年抑郁症，有较好的安全性。
Objective To explore the efficacy and safety of low frequency repetitive transcranial magnetic stimulation（rTMS） for adolescent patients with first-episode depression. Methods Totals of 30 adolescent first-episode depression patients with no medication were randomly divided into rTMS group （15 cases） and control group （15 cases）. Low frequency rTMS located on right dorsolateral prefrontal cortex （DLPFC）was used in rTMS group for 2 weeks （5 times per week）, compared with sham stimulation in control group. No drug was used during treatment. The efficacy was assessed by Hamilton Depression Scale （I-IAMD24）. Results （1） There was significant difference between two groups on effective rate（100% vs 0%, P 〈 0.01）. （2）There was significant reduction both in HAMD24 total scores and in sub-scale factors＇ scores in rTMS group after treatment （P 〈 0.05）. But there was no significant differences in control group （P 〉 0.05）. （3） No significant difference was found in incidence of adverse reaction between two groups （P 〉 0.05）. Conclusions Low frequency rTMS can effectively and safely improve adolescent patients with first-episode depression.
出处
《神经疾病与精神卫生》
2017年第2期85-88,共4页
Journal of Neuroscience and Mental Health
基金
广东省医学科学技术研究基金项目（A2015071）
