摘要
目的探讨脑波治疗对青少年期精神分裂症患者认知功能的影响。方法随机将年龄在12-18岁之间符合DSM-IV精神分裂症标准患者46例,分为单纯应用奥氮平治疗组（实验组1）及应用脑波联合奥氮平治疗组（实验组2）,选择23例健康者作为对照组。实验组予奥氮平治疗8周前后予《简明精神状况检查量表》（BPRS）评分,各组分别予P300检测,分别比较P300潜伏期及波幅的差异。结果实验组1、实验组2PZ点潜伏期均比对照组延长,实验组1、实验组2FZ、CZ、PZ、OZ点波幅均比对照组降低（P〈0.05及0.01）。治疗后,实验组1、实验组2PZ点潜伏期均比治疗前缩短（P〈0.01）;实验组1、实验组2FZ、CZ、PZ、OZ点波幅均比治疗前升高（P〈0.05及0.01）。实验组2PZ点潜伏期比实验组1缩短（P〈0.05）;实验组2FZ、CZ、PZ、OZ点波幅均比实验组1升高（P〈0.05及0.01）。治疗后,实验组1BPRS评分高于实验组2（P〈0.01）,实验组2显效率及总有效率明显高于实验组1（P〈0.01）。结论脑波治疗通过调节、平衡人体的脑电活动及兴奋水平,具有辅助改善青少年期精神分裂症患者认知功能的作用。
Objective To study the effects of brain wave therapy on cognitive function in adolescent schizophrenia. Methods 46 patients （among 12-18 years old） met with DSM-IV for schizophrenia criteria were divided into Olanzapine treated group （research group 1） and brain wave therapy combined Olanzapine treated group （research group 2） randomly. All groups were assessed with BPRS and measured with auditory evoked event-related potential P300 before and after 8 weeks treatment. 23 healthy adolescents were selected as normal control group. P300 latencies and amplitudes of all groups were compared with respectively. Results P3 lateneies prolonged and the amplitudes of FZ, CZ, PZ and OZ site shortened in research group 1, 2 compared with normal control group （P〈20. 05 or P〈0. 01）. After treatment, P3 latencies reduced and the amplitudes of FZ, CZ, PZ and OZ site hoisted in research group 1, 2 （P〈0.05 or P〈0. 01）; P3 latencies reduced,and the amplitudes of FZ, CZ, PZ and OZ site shortened in research group 2 compared with research group 1 （P〈0. 05 or P〈0.01）. The BPRS scores of research group 1 are more than research group 2 after treatment （P〈0. 01）. Conclusion Brain wave therapy could improve the cognitive function in adolescent schizophrenia by adjusting and balancing brain electric activity and excited level.
出处
《中国健康心理学杂志》
2008年第11期1261-1263,共3页
China Journal of Health Psychology
基金
南京医科大学科技发展基金资助项目(NY0587)
