摘要
目的探讨半胱氨酸蛋白酶抑制剂C(CYSC)水平与脑白质疏松的相关性及不同程度脑白质疏松患者血清CYSC水平的差异。方法选择213例脑白质疏松患者(脑白质疏松组)和201名健康体检者(对照组)为研究对象。应用胱抑素C检测试剂盒(乳胶增强免疫比浊法)检测血清CYSC水平,收集临床资料和脑白质疏松的相关可能危险因素,采用MRI的Fazekas方法对脑白质疏松组进行分级,评估不同程度脑白质疏松患者的CYSC水平差异。结果脑白质疏松组的高血压病、糖化血红蛋白、肾功能、同型半胱氨酸和CYSC水平[(0.99±0.28)mg·L^(-1)]与对照组[(0.80±0.20)mg·L^(-1)]比较,差异有统计学意义(P<0.05),提示这些因素和CYSC水平与脑白质疏松的发生和严重程度相关。结论对不同脑白质疏松患者进行影像学Fazekas分级后发现,随着Fazekas评分增加CYSC水平随之升高。
Aim To explore the relationship between the level of cystatin C （CYSC） and leukoaraiosis, as well as the level of CYSC in different degrees of leukoaraiosis. Methods The clinical data were studied between 213 patients with leukoaraiosis and 201 normal control to estimate the risks of leukoaraiosis, Fazekas grading of leukoaraiosis were evaluated to analyze the CYSC level in different degree of leukoaraiosis. ReSults There were significant difference between the normal control and patients with leukoaraiosis in hypertension, glycosylated hemoglobin, renal function, plasma homocysteine and CYSC （P〈0.05）, which indicated that they were related to the occurrence of cerebral white matter lesions. Conclusion The patients with leukoaraiosis were classified by image of MRI, and the results indicated that CYSC level were raised with the increased scores in leukoaraiosis.
出处
《中国临床神经科学》
2017年第2期165-169,共5页
Chinese Journal of Clinical Neurosciences
基金
国家自然科学基金面上项目(编号:81271303)
