摘要
[目的]观察环磷腺苷葡胺治疗急性脑梗死的临床疗效。[方法]采用双盲随机分组、平行对照研究的临床实验原则,治疗组120例,在常规治疗的基础上加用环磷腺苷葡胺;对照组80例,给予内科常规药物治疗;对2组病例在治疗前、治疗结束后的神经功能缺损评分和抽血检查血液流变学情况进行对比。[结果]2组患者经治疗后神功功能缺损评分均有显著改善(P<0.05),且治疗组总有效率为97.12%,对照组总有效率为80.31%,2组总有效率比较有显著差异(P<0.01)。治疗组在调节血液流变学方面优于对照组(P<0.05)。[结论]环磷腺苷葡胺对急性脑梗死患者的神经功能障碍具有良好的改善作用,可提高治愈好转率。
[Objective]To explore the efficacy of acute cerebral infarction treated by meglumine adenosine cyclophosphate. [Methods] By the principle of clinical trims of a double-blind randomized,parallel control study, 200 patients with acute cerebral infarction were randomly divided into two groups： Control group （n = 80） received conventional therapy, and the observation group （n = 120） accepted cAMP meglumine based on the conventional therapy. Serum samples was obtained from the all patients at the time before and after treatment; blood rheology was determined and to evaluate clinical neurological deficit scores of the both groups by national institute of health stroke scale. [ Results ] 1. Before and after treatment, neurologie impairment difference scores of the observation group and control group were significant difference （P 〈 0.05）, and the observation group total effective rate was 97.12%, the control group total effective rate was 80.31%, the two groups total effective rate was significant difference （P 〈 0.01）. 2. The observation group in regulating blood rheology is better than that in control group （P 〈 0.05）. [Conclusion]Meglumine adenosine eyclophosphate has good effect for dysfunction in the early acute cerebral infarction, which can improve the cure rate.
出处
《河南大学学报（医学版）》
CAS
2017年第1期45-47,共3页
Journal of Henan University:Medical Science
