摘要
目的探讨早期糖尿病肾脏疾病(diabetic kidney disease,DKD)患者尿肾损伤因子-1(KIM-1)及β_2-微球蛋白(β_2-MG)含量变化与湿热兼夹证的关系,为早期DKD肾小管损伤的诊断及湿热兼夹证的判定提供客观依据。方法选择60例糖尿病患者,其中30例为单纯糖尿病患者(DM组)、30例为DKDⅢ期患者(DKD组),并对DKD组按中医辨证分为湿热兼夹证组、非湿热兼夹证组。选取体检中心30例同期体检健康人群为对照组(NC组)。采用酶免法检测各组尿KIM-1、β_2-MG含量。结果 DKD组患者尿KIM-1、β_2-MG含量均高于DM组及NC组(P<0.05);湿热兼夹证组患者尿KIM-1、β_2-MG含量较非湿热兼夹证组升高,差异有统计学意义(P<0.05)。结论早期DKD患者存在肾小管损伤,尿KIM-1和β_2-MG含量升高可作为早期DKD肾小管损伤的标志和湿热兼夹证的客观指标。
ABSTRACT Objective To explore the relationships between urine KIM-1, β2-MG of early stage of diabetic kidney disease （DKD） and combined damp-heat syndrome, and provide objective evidence for making diagnosis of early renal tubular injury of DKD and combined damp heat syndrome. Methods 60 cases of diabetic patients were selected including 30 cases of simple diabetic patients （ DM group） and 30 cases of stage III diabetic patients （ DKD group）. The DKD group was further sorted into damp-heat group and non- damp-heat group based on TCM differentiation. 30 healthy people who came to our Health Examination Center during the same period were alaso selected as the control group （NC group）. ELISA was used to detect the level of urine KIM-1 and urine β2-MG. Results The level of urine KIM-1 and urine β2-MG of DKD group were higher than that of DM group and NC group（P 〈0. 05） ; compared to the non-damp-heat group, damp-heat group showed higher concentration of urine KIM-1 and urine β2-MG, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion Renal tubular injury presents at the early stage of DKD and the rising of urine KIM-1 and urine β2-MG can be considered as the early sign of renal tubular injury in early DKD and objective index for combined damp-heat syndrome.
出处
《北京中医药》
2017年第2期128-130,共3页
Beijing Journal of Traditional Chinese Medicine
基金
全军中医药科研专项(2010-ZYZ-104)
