摘要
目的探讨尿肾损伤因子-1(KIM-1)、尿微量清蛋白(mALB)、β2微球蛋白(β2-MG)联合检测对2型糖尿病(T2DM)早期肾损伤的诊断价值。方法 81例T2DM患者分为糖尿病肾病(DN)组38例,不伴DN组43例,以45例健康体检者为健康对照组。尿KIM-1用酶联免疫吸附法(ELISA)测定,尿mALB和β2-MG用全自动生化分析仪测定。结果 T2DM患者尿KIM-1、mALB、β2-MG水平明显高于健康对照组(P<0.01);T2DM患者DN组尿KIM-1、mALB、β2-MG水平明显高于不伴DN组(P<0.05);联合检测阳性率达93.8%,明显高于单项检测。结论联合检测尿KIM-1、mALB和β2-MG对T2DM早期肾损伤的诊断更为敏感。
Objective To explore the value of associated detection of urine kidney injury molecule-1（KIM-1）,urinary microalbumin（mALB） and β2-microglobulin（β2-MG） for the diagnosis of early diabetic nephropathy.Methods 81 patients with type 2 diabetes mellitus（T2DM） were divided into DM group（43 cases） without diabetic nephropathy（DN） and DN group（38 cases）.Healthy subjects（45 cases） were enrolled as control group.Urine KIM-1 was detected by ELISA,and mALB and β2-MG were examined by automatic biochemical analyzer.Results In all patients with T2DM,urine levels of KIM-1,mALB and β2-MG were significantly higher than those in control group（P〈0.01）,and in DN group were significantly higher than in DM group（P〈0.05）.The positive rate of combined detection of KIM-1,mALB and β2-MG was 93.8%,significantly higher than that of single test.Conclusion Urine KIM-1,mALB and β2-MG might be sensitive indicators of early diabetic renal injury,and combined detection could be more sensitive.
出处
《国际检验医学杂志》
CAS
2012年第13期1578-1579,共2页
International Journal of Laboratory Medicine
关键词
糖尿病
2型
糖尿病肾病
肾损伤因子-1
尿微量白蛋白
Β2微球蛋白
Objective To explore the value of associated detection of urine kidney injury molecule-1（KIM-1）,urinary microalbumin（mALB） and β2-microglobulin（β2-MG） for the diagnosis of early diabetic nephropathy.Methods 81 patients with type 2 diabetes mellitus（T2DM） were divided into DM group（43 cases） without diabetic nephropathy（DN） and DN group（38 cases）.Healthy subjects（45 cases） were enrolled as control group.Urine KIM-1 was detected by ELISA,and mALB and β2-MG were examined by automatic biochemical analyzer.Results In all patients with T2DM,urine levels of KIM-1,mALB and β2-MG were significantly higher than those in control group（P〈0.01）,and in DN group were significantly higher than in DM group（P〈0.05）.The positive rate of combined detection of KIM-1,mALB and β2-MG was 93.8%,significantly higher than that of single test.Conclusion Urine KIM-1,mALB and β2-MG might be sensitive indicators of early diabetic renal injury,and combined detection could be more sensitive.
