摘要
目的探讨急性冠脉综合征(ACS)患者白介素-6(IL-6)与全球急性冠状动脉事件注册(Grace)评分之间的关系。方法入选2015年6月~2016年8月首都医科大学附属北京天坛医院心脏重症监护病房(CCU)首次诊断的ACS患者104例,根据Grace评分,将患者分为低危组(Grace评分≤108分)、中危组(Grace评分109~140分)和高危组(Grace评分>140分)。检测IL-6,将IL-6水平从低到高按四分位数分成Q1~Q4组。分析IL-6与Grace评分的相关性。结果 Grace评分高危组患者IL-6高于中危组(P<0.01)和低危组(P<0.01)。Q4组Grace分值及高危百分比都高于Q4以下组(P<0.05)。相关分析显示,IL-6与Grace评分呈正相关(r=0.269,P<0.05)。结论ACS患者IL-6与Grace评分明显正相关,IL-6可能成为ACS患者预后判断的重要血清标志物。
Objective To investigate the relationship between serum interleukin-6（IL-6） level and Global Registry of Acute Coronary Events（Grace） score in patients with acute coronary syndrome（ACS）. Methods The 104 ACS patients who came from Coronary Care Unit in Beijing Tiantan Hospital, Capital Medical University from June 2015 to August 2016 were enrolled in the present study. Serum IL-6 was measured. All the patients were divided into three groups according to Grace risk score： low risk group（≤108 score）, moderate risk group（109-140 score） and high risk group（〉140 score）.According to the IL-6 level, patients were stratified into 4 groups by quartile（from the lowest to the highest, Q1-Q4）. The relationship between serum IL-6 1evel and Grace risk scores in ACS patients was analyzed. Results The IL-6 level was significantly higher in high risk group than that in low risk group（P 〈 0.01） and moderate risk group（P 〈 0.01）. As compared with Q1-Q3 group, the Grace risk score and percentage of high risk patients were higher in the Q4 group（P 〈0.05）. Correlation analysis found that IL-6 was positively associated with Grace risk score（r=0.269, P 〈 0.05）. Conclusion The IL-6 is positively associated with Grace risk score in ACS patients, and IL-6 maybe an important biomarker for prognosis prediction of ACS patients.
出处
《中国医药导报》
CAS
2017年第8期76-79,共4页
China Medical Herald
基金
首都医科大学基础-临床科研合作基金(15JL55)
