全球急性冠状动脉事件注册评分联合血清肌钙蛋白I浓度在急性非ST段抬高型心肌梗死危险分层中的意义被引量：3

Significance of Global Registry of Acute Coronary Events Risk Score and Serum Cardiac Troponin I Concentration in the Risk Stratification of Non ST Segment Elevation Myocaridial Infarction

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摘要目的研究急性非ST段抬高性心肌梗死(NSTEMI)患者血清肌钙蛋白I(c Tn I)浓度与全球急性冠状动脉事件注册(GRACE)评分的关系,探讨GRACE低评分联合血清c Tn I浓度对NSTEMI患者发生院内心血管事件的预测价值。方法选取2011年1月-2012年12月收治的168例NSTEMI患者为研究对象。对其进行入院即刻及第2天(入院后24 h内)血清c Tn I浓度测定,取其峰值浓度,同时应用GRACE评分软件计算患者GRACE积分水平,并进行危险分层:低危组48例,中危组75例,高危组45例;住院期间行常规治疗。结果高危组血清c Tn I浓度、主要不良心血管事件(MACE)发生率高于中危组和低危组(P<0.05),中危组c Tn I浓度与MACE发生率亦高于低危组(P<0.05)。低危组住院期间发生MACE与未发生MACE患者年龄、是否合并高脂血症、血清c Tn I差异有统计学意义(P<0.05)。结论 NSTEMI患者GRACE低评分,血清c Tn I浓度越高,MACE发生率越高,在GRACE低评分组中联合c Tn I浓度对NSTEMI的MACE风险评估中具有一定的临床价值。 Objective To study the relationship between plasma cardiac troponin I（c Tn I） and global registry of acute coronary events（GRACE） risk score in patients with acute non ST segment elevation myocardial infarction（NSTEMI）, and to assess the value of low GRACE risk score combined with plasma c Tn I concentration in predicting hospital cardiovascular events in NSTEMI patients. Methods A total of 168 patients with NSTEMI treated between January 2011 and December 2012 were included in this study. h eir serum CTn I level was measured instantly and on the second day（within 24 hours） to get the peak value. GRACE risk score was calculated by computer rating sot ware. According to the GRACE risk score, risk stratii cation was performed, and patients were divided into low-risk group（n=48）, middle-risk group（n=75） and high-risk group（n=45）. Routine treatment was carried out for the patients during hospitalization. Results h e serum c Tn I peak value was higher in high-risk patients than that in low-risk patients and middle-risk patients（P〈0.05）. h e c Tn I peak value was signii cantly higher in the middle-risk patients than in the low-risk patients（P〈0.05）. h e incidence of major adverse cardiovascular events（MACE） in low-risk patients with higher serum c Tn I peak value was relatively higher. Age, hyperlipidemia, and serum c Tn I were closely related to MACE（P〈0.05）. Conclusions For NSTEMI patients with a low GRACE score, the MACE rate increases with the increase of serum c Tn I concentration. GRACE low score and c Tn I concentration have a certain clinical value in assessing the risk of MACE in NSTEMI patients.

作者黄萍王斌

机构地区广汉市人民医院心内科

出处《华西医学》 CAS 2015年第12期2201-2204,共4页 West China Medical Journal

关键词急性非ST段抬高性心肌梗死全球急性冠状动脉事件注册评分血清肌钙蛋白I 心血管事件 Acute non ST segment elevation myocardial infarction Global registry of acute coronary events risk score Serum cardiac troponin I Cardiovascular events

分类号 R541.4 [医药卫生—心血管疾病]

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