摘要
目的研究拉莫三嗪辅助小剂量丙戊酸治疗癫痫的可行性。方法将我院2015年3月~2016年3月收治的62例癫痫患者随机分为观察组和对照组各,31例。对照组患者给予小剂量丙戊酸静脉注射治疗,观察组患者在此基础上加用拉莫三嗪口服治疗。比较两组患者的治疗效果,治疗前后癫痫发作及不良反应发生情况,分析观察组患者丙戊酸与拉莫三嗪血药浓度的相关性。结果观察组患者治疗总有效率93.55%,显著高于对照组的74.19%(P<0.05);两组患者治疗后的癫痫发作次数、持续时间、痫样放电及累及导联数均较治疗前显著下降(P<0.01),且治疗后观察组患者的癫痫发作次数、持续时间、痫样放电及累及导联数显著低于对照组(P<0.01);观察组患者丙戊酸和拉莫三嗪血药浓度成正相关(r=0.952,P<0.05);两组患者的不良反应发生率差异无统计学意义(P>0.05)。结论拉莫三嗪辅助小剂量丙戊酸可有效控制癫痫发作,提高治疗效果,安全性较高。
Objective To research the feasibility of Lamotrigine combined with low-dose Valproic Acid treating epilepsy. Methods A total of 62 patients with epilepsy who were treated in our hospital from March 2015 to March 2016 were enrolled in and randomly divided into observation group and control group,with 31 patients in each group.The observa- tion group was treated with Lamotrigine combined with Valproic Acid,while the control group was treated with Valproic Acid.The clinical effect,epilepsy seizure and incidence of adverse reaction of patients between two groups were com- pared.The correlation of blood concentration of Lamotrigine and Valproie Acid in observation group were analyzed. Results The total effective rate of observation group （93.55%） was significantly higher than that of control group （74.19%） （P〈0.05）.The number of seizures,duration time,epileptic discharge and the number of lead involved of the two groups were all significantly lower after treatment（P〈0.01） and the related indicators in observation group were all significantly lower than those in control group （P〈0.01）.The correlations of blood concentration between Lamotrigine and Valproic Acid in observation group was positive （r=0.952,P〈0.05）.There was no statistical difference of incience rate of adverse reaction between two groups （P〉0.05）.Conclusion Lamotrigine combined with Valproic Acid can control seizure and significantly improve the clinical effect treating epilepsy.
出处
《中国当代医药》
2017年第7期70-72,共3页
China Modern Medicine
关键词
拉莫三嗪
丙戊酸
癫痫
Lamotrigine
Valproic acid
Epilepsy
