摘要
目的探讨拉莫三嗪联合小剂量丙戊酸治疗新诊断癫痫的临床疗效。方法收集2013年1月至2014年12月100例新诊断癫痫患者随机分为两组,对照组患者给予小剂量丙戊酸治疗,实验组患者则加服拉莫三嗪,比较两组患者整体治疗效果、治疗前后发作指标、治疗前后癫痫相关指标与治疗期间不良反应发生情况等。结果实验组患者总体治疗总有效率(94.0%)明显高于对照组(78.0%),差异有统计学意义(P<0.05);实验组患者治疗后发作次数与发作持续时间显著低于对照组,差异有统计学意义(P<0.01);实验组患者治疗后痫样放电与累及导联数水平显著低于对照组,差异有统计学意义(P<0.01);两组患者总体不良反应发生率(16.0%vs.8.0%)差异无统计学意义(P>0.05)。结论拉莫三嗪联合小剂量丙戊酸治疗新诊断癫痫的临床疗效较高,且安全性好,值得推广应用。
Objective To investigate lamotrigine, the clinical efficacy of a new diagnosis of epilepsy small dose of valproate combination therapy. Methods From January 2013 to December 2014 admitted one hundred patients with newly diagnosed epilepsy patients were randomly di- vided into two groups, the control group were treated with small doses of valproic acid treatment, the experimental group were then given additional lamotrigine, overall treatment were compared before and after the onset of treatment indicators related indicators before and after the treatment of epilepsy and adverse events during the treatment and the like. Results The overall treatment of patients overall response rate （94.0%） was sig- nificantly higher （78.0%）, there was a significant difference（ P 〈0.05） ; the number of times after the onset of the experimental group patients and seizure duration was significantly lower than comparison between the two groups in the control group, there was a significant difference（ P 〈 0.01 ） ; experimental group patients epileptiform discharges and the number of leads involved level between the two groups was significantly lower than the control group, there are significant difference（ P 〈 0.01 ） ; the overall incidence of adverse reactions two groups of patients （16.0% vs.8.0% ） , there was no significant difference （ P 〉 0. 05 ）. Conclusion Lamotrigine, valproate combination therapy of low - dose clinical efficacy of newly diagnosed epilepsy, and high security, with reference.
出处
《临床和实验医学杂志》
2016年第21期2123-2125,共3页
Journal of Clinical and Experimental Medicine
关键词
癫痫
拉莫三嗪
丙戊酸
不良反应
Epilepsy
Lamotrigine
Valpreic acid
Adverse reactions
