摘要
目的探讨载脂蛋白E(ApoE)基因多态性与血脂水平的相关性。方法采用实时荧光聚合酶链反应(PCR)对体检人群进行ApoE基因分型检测,比较不同ApoE基因型人群的血脂水平。结果人群中ApoE基因呈多态性分布,其中E3等位基因分布频率最高;含有等位基因E2的人群三酰甘油水平较高,含有等位基因E4的人群总胆固醇水平较高。结论人群中ApoE基因呈多态性分布,其中E2等位基因与血清高三酰甘油水平相关,E4等位基因与血清高总胆固醇水平相关。
Objective To explore the correlation between apolipoprotein E（ApoE）genetic polymorphism and serum lipid levels.Methods The real-time fluorescence PCR method was adopted to detect the ApoE genotype in people undergoing physical examination.The serum lipid levels were compared among the populations with different ApoE genotypes.Results The ApoE gene showed the polymorphic distributions in populations,in which the distribution frequency of E3 allele was highest,the population containing E2 allele had higher triglycerides level in serum,the population containing E4 allele had higher total cholesterol level in serum.Conclusion The ApoE gene presents the polymorphic distribution in populations,in which the E2 allele is correlated with serum high triglycerides level;the E4 allele is correlated with serum high total cholesterol level.
出处
《检验医学与临床》
CAS
2017年第6期814-815,共2页
Laboratory Medicine and Clinic
关键词
载脂蛋白E
基因多态性
三酰甘油
总胆固醇
apolipoprotein E
genetic polymorphism
triglycerides
total cholesterol
