摘要
目的探讨慢性肾脏病(CKD)患者血清鳞状细胞癌抗原(SCC)与β_2微球蛋白(β_2-MG)的变化及指标之间的相关性。方法 CKD患者96例纳入试验组,同期106例健康体检者纳入对照组;按照肾小球滤过率将CKD患者分为CKD 1期21例,CKD 2期15例,CKD 3期25例,CKD 4~5期35例;检测试验组和对照组研究对象的血清SCC,β_2-MG和肌酐水平,分析CKD患者血清SCC与β_2-MG的变化及其相关性。结果试验组中CKD患者血清SCC、β_2-MG和肌酐水平显著高于对照组,差异均有统计学意义(P<0.05),且随着病情的加重3个指标都明显升高(P<0.05);血清SCC水平与β_2-MG呈正相关(r=0.719,P<0.05),与肌酐也呈正相关(r=0.756,P<0.05);血清SCC、β_2-MG和肌酐3个指标诊断CKD的曲线下面积分别为0.921、0.955、0.949。结论 CKD患者血清SCC、β_2-MG和肌酐水平均显著升高,对CKD有较大的诊断价值,而且血清SCC与β_2-MG、肌酐均具有较强的相关性。
Objective To explore the change of serum SCC and β2 microglobulin（β2-MG）in the patients with chronic kidney disease（CKD）and their correlation.Methods A total of 96 CKD patients were included into the experimental group and contemporaneous 106 persons undergoing physical examination were included into the control group;the CKD patients were divided into the stage 1 group（n=21）,stage 2 group（n=15）,stage 3 group（n=25）and stage 4-5 group（n=35）by GFR.The levels of serum SCC,β2-MG and creatinine in the experimental and control groups were detected;the changes of serum SCC andβ2-MG were analyzed and the correlation between them in CKD patients were analyzed.Results The levels of serum SCC,β2-MG and creatinine in the experimental group were significantly higher than those in the control group and the difference had statistical significance（P〈0.05）;the three indicator′s values were significantly increased with the disease condition aggravation（P〈0.05）;the positive correlation was demonstrated between serum SCC andβ2-MG（r=0.719,P〈0.05）and between serum SCC and creatinine（r=0.756,P〈0.05）;the areas under the curve of serum SCC,β2-MG and creatinine for diagnosing CKD were 0.921,0.955 and 0.949 respectively.Conclusion The levels of serum SCC,β2-MG and creatinine in CKD patients are increased significantly,which have a greater diagnostic value for CKD,moreover the serum SCC shows stronger correlations withβ2-MG and creatinine.
出处
《检验医学与临床》
CAS
2017年第6期756-758,共3页
Laboratory Medicine and Clinic
基金
国家临床重点专科建设项目(财社[2010]305号)
关键词
慢性肾脏病
鳞状细胞癌抗原
Β2-微球蛋白
肌酐
chronic kidney disease
squamous cell carcinoma antigen
β2-microglobulin
creatitine
