摘要
目的监测宫颈鳞癌患者血清鳞状细胞癌相关抗原(SCC-Ag)值的变化,探讨其在临床诊断、判定疗效及预后中的作用。方法对30名健康人以及经临床病理确诊的19例非鳞状细胞宫颈癌患者和120例鳞状细胞宫颈癌患者,采用雅培公司提供的全自动免疫分析系统(Axsym)检测血清SCC-Ag数值,比较分析该抗原改变的临床意义。结果健康人、非鳞状细胞宫颈癌患者和鳞状细胞宫颈癌患者SCC-Ag阳性率分别为3.33%、15.79%和70.83%,三个阳性率差别有显著性意义(P<0.01);宫颈癌患者的临床分期与SCC-Ag有相关性(P<0.01),中晚期宫颈癌患者的SCC-Ag数值显著高于早期患者(P<0.01);临床复发与预后同SCC-Ag有相关性(P<0.01),复发患者治疗前SCC-Ag数值显著高于未复发者(P<0.01)。结论血清SGG-Ag的测定对宫颈鳞癌具有辅助诊断的作用,同时监测宫颈鳞癌患者的血清SGG-Ag水平具有一定的证实疗效和推测预后的作用,尤其对监控宫颈鳞癌的复发具有重要意义。
Objective Observe the application of squamous cell carcinoma antigen（SCC-Ag） in the diagnosis and clinical monitor of the cervical squamous carcinoma. Methods The serum SCC-Ag was measured by Axsym in the 30 healthy people, 19 other types cervical carcinoma patients and 120 cervical squamous carcinoma patients, to analyze the clinical significance of SCC-Ag. Results The positive rate of the healthy people was 3.33% , 15.79% in other types cervical carcinoma patients, 70.83% in the cervical squamous carcinoma patients ,there were significant differences among three groups（P〈0.01）. The level of serum SCC-Ag was closely related to the clinical stage of cervical squamous carcinoma（P〈0.01） ,the level of SCC-Ag in the Ⅲ、Ⅳ stages was significantly higher than 0,1 stages（P〈0.01） ; the level of SCC-Ag was obviously higher in recur patients than the Non-recur patients（P〈0.01）, there were significant for the clinical precaution. Conclusion SCC-Ag is useful in diagnosis and clinical monitor for cervical squamous carcinoma , especially of monitoring the recur patients.
出处
《辽宁医学杂志》
2005年第5期244-245,共2页
Medical Journal of Liaoning
