摘要
目的探讨DC-CIK辅助治疗对老年晚期卵巢癌病人T细胞亚群和生活质量的影响。方法选择本院收治的62例老年晚期卵巢癌病人作为研究对象,随机将其分为观察组和对照组,每组各31例,其中对照组给予TP化疗方案,观察组在对照组基础上联合DC-CIK辅助治疗方法,对比2组病人T细胞亚群和生活质量的情况。结果治疗后观察组CD3^+、CD3^+/CD4^+、CD4^+/CD8^+和NK细胞的水平显著高于对照组和治疗前,差异均有统计学意义(P<0.05),而CD4^+/CD25^+和CD3^+/CD8^+水平显著低于对照组和治疗前,差异均有统计学意义(P<0.05);观察组近期有效率为87.10%,显著优于对照组的54.84%,2组比较差异有统计学意义(P<0.05);观察组治疗后有15例病人卡氏评分提高>20分,显著优于对照组的3例;观察组不良反应中骨髓抑制(主要以Ⅲ度和Ⅳ度为主)及肝功能损害发生率显著低于对照组,2组比较差异均有统计学意义(P<0.05)。结论老年晚期卵巢癌病人在术后应用DC-CIK细胞免疫辅助治疗不仅可提高其Th1类因子的抗肿瘤作用,有效提高T淋巴细胞的免疫学功能,而且还能显著改善病人生活质量,在临床应用过程中安全性较高,值得推广应用。
Objective To investigate the effects of DC-CIK on the T cell subsets and the quality of life in elderly patients with advanced ovarian cancer. Methods Sixty-two cases of elderly patients with advanced ovarian cancer were randomly divided into observation group and control group with 31 cases in each group. The control group was given TP chemotherapy,and the observation group was treated with DC-CIK cell immune adjuvant therapy based on the control group. T cell subsets and the quality of life were compared between the two groups. Results After treatment,the levels of CD3^＋,CD3^＋/CD4^＋,CD4^＋/CD8^＋and NK cells in the observation group were significantly higher than those in the control group and before treatment（ P〈0. 05）,and CD4^＋/CD25^＋and CD3^＋/CD8^＋levels were significantly lower than those of the control group and before treatment（ P〈0. 05）. The effective rate of the observation group was87. 10%,which was significantly higher than that of the control group（ 54. 84%）（ P〈0. 05）. After treatment,15 cases of patients in the observation group showed an increase of more than 20 points in karnofsky score,comparted with 3 cases in control group. Adverse reactions of observation group were bone marrow suppression（ mainly to grade Ⅲ and Ⅳ） and liver damage,and the incidence rate was significantly lower than that of the control group（ P〈0. 05）. Conclusions In the elderly patients with advanced ovarian cancer,DC-CIK cell immune adjuvant therapy can not only improve the anti-tumor effect of Th1,and effectively improve the immune function of T lymphocytes,but also significantly improve the quality of life of patients with high safety.
作者
张勇
ZHANG Yong.(Department of Gynecology, the First People＇s Hospital of Hanchuan City, Hanchuan 431600, China)
出处
《实用老年医学》
CAS
2017年第3期257-260,共4页
Practical Geriatrics
