摘要
目的:探讨射干麻黄汤治疗老年慢性支气管炎急性发作的临床疗效研究及机制。方法:研究对象为78例老年慢性支气管炎急性发作患者,随机分成两组,每组39例。对照组给予莫西沙星、盐酸氨溴索片以及氨茶碱缓释片等综合治疗,治疗组在此基础上再予射干麻黄汤治疗,均接受10 d治疗。检测血清炎性因子水平,予治疗前后动脉血气分析,记录主要症状缓解时间及住院时间,比较临床疗效。结果:与治疗前比较,两组血清IL-6、PCT及hs-CRP水平显著降低(P<0.01),IL-2及PaO_2水平显著升高(P<0.01),PaCO_2明显降低(P<0.01);与对照组比较,治疗组血清IL-6、PCT及hs-CRP水平较低(P<0.01),IL-2水平较高(P<0.01),PaO_2较高(P<0.01),PaCO_2较低(P<0.01),咳、痰、喘及住院时间较短(P<0.01),治疗有效率较高(P<0.05)。结论:射干麻黄汤可有效快速缓解老年慢性支气管炎急性发作期主要症状,提高临床疗效,且安全可靠。
Objective： To explore the clinical effect and mechanism of Belamcanda and Ephedra Decoction in the treatment of acute episode of elderly chronic bronchitis. Methods： A total of 78 cases of elderly patients with acute episode of chronic bronchitis were randomly divided into two groups,39 cases in each. Control group received moxifloxacin,Ambroxol Hydrochloride Tablets and Aminophylline Sustained-release Tablets and other comprehensive treatment. The treatment group additionally received Belamcanda and Ephedra Decoction for 10 days. Serum inflammatory factor level,arterial blood gas analysis,symptom relief time and length of stay and clinical efficacy were compared after the treatment. Results： Compared with those before treatment,serum levels of IL-6,PCT and CRP in two groups decreased（ P〈0. 01） and IL-2 and PaO_2 levels increased significantly（ P〈0. 01） and PaCO_2 significantly reduced（ P〈0. 01）. Compared with the control group,the serum levels of IL-6,PCT and CRP in treatment group were lower（ P〈0. 01） and IL-2 and PaO_2 levels higher（ P〈0. 01） and PaCO_2 lower（ P〈0. 01）. Cough,phlegm,dyspnea and short hospitalization time were lower（ P〈0. 01） and the effective rate was higher（ P〈0. 05）. Conclusion： Belamcanda and Ephedra Decoction in the treatment of acute episode of chronic bronchitis in the elderly was effective with high safety.
出处
《辽宁中医杂志》
CAS
北大核心
2017年第3期531-534,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
慢性支气管炎
急性发作
射干麻黄汤
疗效机制
chronic bronchitis
acute episode
Belamcanda and Ephedra Decoction
mechanism
