摘要
目的:从寒湿毒论治慢性萎缩性胃炎癌前病变患者,观察温中化湿解毒汤对患者的主要症状、体征和胃黏膜萎缩、肠上皮化生(IM)和异型增生(Dys)的影响,在治疗结束后6个月随访疾病复发情况。方法:将符合纳入标准的80例患者,采取随机法分为观察组和对照组各40例,对照组给予胃复春片口服,观察组给予中药温中化湿解毒汤加减治疗,两组均连续治疗26周,统计分析疗效。结果:治疗后观察组在临床疗效方面(总有效率92.50%)优于对照组(总有效率70.00%)(P<0.05),治疗后观察组在胃脘胀痛、喜按喜暖、大便溏薄、气短乏力、纳差等方面的临床治愈率较对照组明显改善(P<0.05),治疗后6个月观察组患者胃黏膜萎缩、IM较对照组好转(P<0.05),两组患者Dys无明显变化。结论:温中化湿解毒汤能较好地改善脾胃虚寒(弱)证CAG患者的主要症状、体征,使胃黏膜萎缩、IM好转或部分恢复正常,复发率降低。
Objective： To observe the influence of Wenzhong Huashi Jiedu Decoction on main symptoms,signs and gastric atrophy,intestinal metaplasia（ IM） and dysplasia（ Dys） of patients with chronic atrophic gastritis and precancerous lesions. The recurrence after six months of treatment was followed up. Methods： Eighty patients who met the inclusion criteria were randomly divided into two groups. The observation group and the control group had 40 patients in each. The control group was given Weifuchun Tablets. The observation group were given traditional Chinese medicine Wenzhong Huashi Jiedu Decoction. Both groups were given 26 weeks of continuous treatment. Results： After treatment,the observation group＇ s clinical efficacy（ total efficiency of 92. 50%） was better than the control group＇s（ total efficiency of 70. 00%）（ P〈0. 05）. The observation group＇s epigastric pain,the clinical cure rate,shortness of breath,fatigue,anorexia and other aspects improved significantly than those of the control group（ P〈0. 05）. After six months of treatment,the observation group＇s gastric atrophy and IM were better than those of the control group（ P〈0. 05）.Two groups had no significant changes in Dys. Conclusion： Wenzhong Huashi Jiedu Decoction can better improve the spleen and stomach（ deficiency） CAG syndrome. The main symptoms,signs and IM improved or recovered partially and the relapse rate reduced.
出处
《辽宁中医杂志》
CAS
北大核心
2017年第3期528-530,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
上海市浦东新区传统型中医临床示范学科建设资助项目(PDZYXK-3-2013008)
周浦医院重点学科建设资助项目(ZP-XK-2015B-5)
关键词
温中化湿解毒汤
脾胃虚寒(弱)证
慢性萎缩性胃炎
癌前病变
临床观察
Wenzhong Huashi Jiedu Decoction
spleen deficiency syndrome
chronic atrophic gastritis
precancerous lesion
clinical observation
