摘要
细胞死亡无论在生理还是在病理条件下都是无法避免的重要环节.传统意义上细胞死亡主要分为凋亡（apoptosis）和坏死（necrosis）两大主要类型,但近年来却发现在诸多病理生理情况下亦有自噬（au-tophagy）、胀亡（oncosis）、副凋亡（paraptosis）、焦亡（pyroptosis）等多种方式参与其中.越来越多细胞死亡方式的发现为进一步明确疾病的发生机制以及为研究人员寻找新的疾病治疗方法提供科学的理论依据.2012年Dixon等[1]首次发现并报道了这一新型细胞死亡方式--铁死亡（ferroptosis）,其确切机制尚有待深入研究.
With the development of modern medical research , it has been found that there are many forms of cell death under lots of physiological or pathological conditions .Among them, necrosis and apoptosis are the 2 main forms of cell death.In recent years, varieties of new cell death patterns, such as autophagy, oncosis and paraptosis, have been discovered.In 2012, Dixon et al first discovered and reported a new form of iron-dependent cell death , ferroptosis.In this review, we try to expound the morphological and biochemical features of ferroptosis and its related diseases in detail , so as to deepen our understanding of cell death , thus providing new ideas for the prevention and treatment of clinically relevant diseases .
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2017年第3期567-571,共5页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.81571108)
关键词
细胞死亡
铁死亡
铁
脂质
活性氧簇
Cell death
Ferroptosis
Iron
Lipids
Reactive oxygen specie
