摘要
通过借鉴Meta分析法分析中国知网数据库(CNKI)中有关鱼源、鳖源嗜水气单胞菌的7种毒力基因的相关研究数据,探讨鱼源、鳖源嗜水气单胞菌毒力基因的分布特点及为研制嗜水气单胞菌多价DNA疫苗提供候选基因。分析结果表明:嗜水气单胞菌毒力基因的分布受养殖对象的种类和生长环境影响;南方和北方地区鱼源嗜水气单胞菌以毒力基因astA、altA、aerA和hlyA分布较为广泛,南方地区鳖源嗜水气单胞菌毒力基因hlyA、actA和aerA分布均较为广泛,可分别作为制备鱼源和鳖源嗜水气单胞菌多价DNA疫苗候选基因。
The data of 7 kinds of virulence genes of Aeromonas hydrophila from fish and turtle in CNKI database were analyzed based on Meta- analysis, and the distribution characteristics of virulence genes of Aeromonas hydrophila from fish and turtle were discussed to provide candi- date gene for generate multivalent DNA vaccine of Aeromonas hydrophila. The results showed that the distribution of virulence genes from Aeromonas hydrophila was affected by the types of cultured species and growth environment. The virulence genes of astA, altA,aerA and hlyA from Aeromortas hydrophila of fish were widely distributed in the north and south of China. The virulence genes of hlyA, actA, and aerA from turtle source Aeromonas hydrophila were. widely distributed in the south of China, which could be used as candidate genes for generating mul- tivalent DNA vaccine of Aeromonas hydrophila in fish and turtle respectively.
作者
牛志伟
吕小丽
黄钧
韩书煜
黎姗梅
梁静真
韦慕兰
邓小红
NIU Zhi-wei LV Xiao-li HUANG Jun HAN Shu-yu LI Shan-mei HANG Jing-zhen WEI Mu-lan DENG Xiao-hong(Institute of Animal Science and Technology of Guangxi University/ Guangxi Aquatic Animal Disease Diagnostic Laboratory, Guangxi Nanning 530005, China Guangxi Luchuan Aquaculture Technology Extension Station, Guangxi Luchuan 537700, China Guangxi Zhuang Autonomous Region, Aquaculture Technology Extension Station, Guangxi Nanning 530005, China Guangxi Duan Yao Autono- mous County Aquaculture Technology Extension Station, Guangxi Du＇ an 530700, China Guangxi Quanzhou Aquaculture Technology Ex- tension Station, Guangxi Quanzhou 541500, China)
出处
《西南农业学报》
CSCD
北大核心
2017年第3期711-716,共6页
Southwest China Journal of Agricultural Sciences
基金
广西水产畜牧兽医局专项项目(桂渔牧财[2014]52号,桂渔牧财[2015]97号)
关键词
嗜水气单胞菌
鱼源
鳖源
毒力基因
META分析
DNA疫苗
Aeromonas hydrophila
Fish derived
Turtle derived
Virulence genes
Meta analysis
DNA vaccine
