摘要
神经退行性疾病是一类常见的神经系统疾病，严重影响患者的生活质量甚至生命安全，因而其发病机理受到人们越来越多的关注。通过对内质网功能的研究，人们逐渐意识到内质网应激与神经退行性疾病的发病机理密切相关。检索中国知网、Pubmed等数据库，选取“神经退行性疾病／neurodegenerative diseases”、“内质网应激／endoplasmic reticulum stress”、“未折叠蛋白反应／unfolded protein response”等为检索词，选择与主题密切相关的文献，重点综述内质网应激与阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿舞蹈症（HD）、肌萎缩性侧索硬化症（ALS）等神经退行性疾病的关系。结果发现在神经退行性疾病中分子伴侣GRP78／Bip、eIF2α的磷酸化水平以及一些ERS相关因子发生改变。说明以内质网应激为研究对象探索神经退行性疾病发病机理与治疗方法可能是该类疾病研究的一个重要突破口。
Neurodegenerative diseases, which are common nervous system diseases, seriously affect people＇s life quality and even lives. So the pathogenesis of neurodegenerative diseases is attracting more and more attention in recent years. People gradually realize that endoplasmic reticulum stress is associated with the pathogenesis of many diseases through studying the function of the endoplasmic reticulum. ＂Neurodegenerative diseases＂ ,＂ endoplasmic reticulum stress＂ ,＂unfolded protein response＂ were used as the key words of retrieval performance in the databases such as Pubmed, CNKI and so on. And the papers which closely related with the theme were chosen to investigate the association between alzheimer＇s disease,parkinson＇s disease,Huntington＇ s disease ,amyotrophic lateral sclerosis and ERS. It turned out that the expression of molecular chaperone GRP78/Bip was increased in all neurodegenerative diseases, and the phosphorylation of eIF2α increased in most neurodegenerative diseases. However, the expression of some ERS-related factors was completely different in different neurodegenerative diseases. Thus, the study of ERS may be an important breakthrough for the pathogenesis and treatment of neurodegenerative diseases.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2017年第2期183-187,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
山东省自然科学基金项目（ZR2015CL021,ZR2014HL040）
济宁医学院基金项目（JY2015KJ001）
关键词
内质网应激
错误折叠蛋白
神经退行性疾病
Endoplasmic reticulum stress
Unfolded protein response
Neurodegenerative diseases
