摘要
腹腔粘连是临床上术后常见的并发症,目前临床上还没有较好的针对性药物,临床防治主要依靠物理手段或激素。钩藤碱是传统中药钩藤的主要有效成分。本课题观察了钩藤碱对实验性腹腔粘连的防治效果,实验结果显示,钩藤碱可剂量依赖地减轻腹腔粘连的程度,显著降低大鼠血清白介素-6(interleukin-6,IL-6)、白介素-1β(interleukin-1β,IL-1β)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)及腹腔液中转化生长因子-β1(transforming growth factor-β1,TGF-β1)和结缔组织生长因子(connective tissue growth factor,CTGF)的蛋白含量。表明其防治腹腔粘连作用的机制可能与抑制炎症因子和TGF-β1/Smad信号通路有关。
Postoperative intra-abdominal adhesion is one of the most common complications in the postoperative period. Current remedies are very ineffective to prevent the pathological outcomes except steroid hormones. Rhynchophylline is deemed as a pharmacologically active component from traditional Oriental medicine Uncaria rhynchophylla（Miq.） Jacks.（Rubiaceae）. This study was designed to investigate the preventative effect of rhynchophylline on the abdominal adhesions in rats. Rhynchophylline relieved the experimental abdominal adhesion and decreased the levels of interleukin-1β（IL-1β）,interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） in the blood serum in a dose-dependent manner. The levels of transforming growth factor-β1（TGF-β1） and connective tissue growth factor（CTGF） were reduced significantly in the peritoneal fluid. The potential mechanism of the activity is related to inhibition of the TGF-β1/Smad signaling pathway.
出处
《药学学报》
CAS
CSCD
北大核心
2017年第2期229-235,共7页
Acta Pharmaceutica Sinica
基金
江苏省2012年度普通高校研究生科研创新计划项目(CXZZ12_0620)
南京中医药大学基础研究与重点培育项目(09XPY05)
河南省高等院校基金(15A31000)
关键词
钩藤碱
腹腔粘连
转化生长因子Β1
结缔组织生长因子
rhynchophylline
abdominal adhesion
transforming growth factor-β1
connective tissue growth factor
