摘要
目的:通过Meta分析评估不同影像导航脑肿瘤切除术和传统手术对比治疗的效果。方法:计算机检索Pub Med、CBM、Cochrane library、Web of Science数据库至2014年11月15日,以获得有关不同影像导航脑肿瘤切除术的随机对照研究。采用Rev Man 5.3软件分析数据,计算比值比(OR)及95%的可信区间,检验异质性并寻找其来源,应用漏斗图评估发表偏倚。结果:总共纳入10篇随机对照研究(RCT),共计669例病人,其中影像导航手术者329例,传统手术者340例。Meta分析结果显示:与传统手术相比,影像导航切除脑肿瘤的全切率较高,术后功能障碍发生率减低,差异具有统计学意义(P<0.05)。在全切率方面,不同影像导航之间无统计学差异(P>0.05)。但在降低术后功能障碍方面,术中磁共振优于超声,超声优于弥散张量成像(DTI)(P=0.02)。结论:影像导航脑肿瘤切除术相比传统手术可以提高肿瘤全切率,最大程度保护功能区,降低术后并发症发生率,从而提高患者生活质量。
Objective： We did a Meta- analysis to evaluate the effect of image- guided brain tumor resection and contrast traditional surgical treatment. Methods： We searched randomized controlled studies in Pub Med,CBM,Cochrane library,Web of Science database to November 15,2014. Using Rev Man 5. 3 software to analyze data. To calculate the odds ratio（ OR） and 95% confidence intervals,test heterogeneity of source,use funnel plot to assess publication bias. Results： 10 randomized controlled studies（ RCT）,a total of 669 patients,including image- guided surgery 329 cases,340 cases of traditional surgery. Meta- analysis showed that： Compared with traditional surgery,image- guided brain tumor resection total resection rate was higher,the low incidence of postoperative dysfunction,the difference was statistically significant（ P〈0. 05）. In total removal rate there was no significant difference（ P〉0. 05） between different image navigation. But in terms of postoperative dysfunction,intraoperative MRI was superior to ultrasound,ultrasound superior to DTI（ P = 0. 02）. Conclusion： Imaging navigation brain tumor resection compared to conventional surgery can improve the rate of total resection of the tumor,protect functional area,reduce the incidence of postoperative complications and improve the patient＇s life quality.
出处
《现代肿瘤医学》
CAS
2017年第6期880-885,共6页
Journal of Modern Oncology
关键词
脑肿瘤
影像导航
随机对照研究
META分析
brain tumor
image navigation
randomized controlled study
Meta-analysis
