摘要
目的了解同型半胱氨酸(Hcy)、叶酸及维生素B_(12)(Vit B_(12))对高血压及其合并症的临床价值。方法检测4 358名体检者Hcy、Vit B_(12)及叶酸,同时收集常规体检资料。根据血压及有无合并症分为单纯高血压组(653例)、高血压合并冠心病(CHD)组(550例)、高血压合并糖尿病(DM)组(386例)、高血压合并多疾病组(154例)和正常对照组(2 615名)。结果 4 358名体检者中检出1 743例高血压患者,检出率为39.99%。正常对照组Hcy、Vit B_(12)、叶酸水平均无异常。单纯高血压组、高血压合并CHD组、高血压合并DM组、高血压合并多疾病组Hcy水平呈线性升高,Vit B_(12)、叶酸水平呈线性降低。与正常对照组比较,其他4个组年龄、体重指数(BMI)、性别比例、嗜烟酒率、Hcy水平及高Hcy血症患病率均明显增高(P<0.05),叶酸、Vit B_(12)水平则明显降低(P<0.05);与单纯高血压组比较,其他高血压各组Hcy、高Hcy血症患病率明显增高(P<0.05),叶酸、Vit B_(12)水平明显降低(P<0.05);与高血压合并CHD组比较,高血压合并DM组和高血压合并多疾病组Hcy水平明显增高(P<0.05),叶酸、Vit B_(12)水平明显降低(P<0.05)。其他项目各组之间差异均无统计学意义(P>0.05)。结论高Hcy、低Vit B_(12)及低叶酸水平是高血压及其合并症的危险因素。高血压还与年龄、嗜烟酒及BMI有关。
Objective To investigate the clinical significance of homocysteine （ Hcy ） , folic acid and vitamin B12 （ Vit Bn ） for hypertension and its complications. Methods A total of 4 358 subjects were enrolled and determined for Hcy, folic acid and Vit Bu, and other information of healthy examination was collected. According to hypertension and its complications, they were classified into simple hypertension group （ 653 cases ） , hypertension with coronary heart disease （ CHD ） group （ 550 cases ） , hypertension withs diabetes mellitus （ DM） group （ 386 cases ） , hypertension with other disease group （ 154 cases ） and healthy control group （2 615 cases） . Results There were 1 743 cases with hypertension, and its determination rate was 39.99%. The levels of Hcy, Vit B12 and folic acid in healthy control group were normal. The Hcy levels of simple hypertension group, hypertension with CHD group, hypertension with DM group and hypertension with other disease group increased linearly, and the levels of Vit Bn and folic acid decreased linearly. Compared to healthy control group, age, body mass index （ BMI） , sex proportion, the rates of tobacco and alcohol abuses, Hcy level and hyperhomocysteinemia rate of the other 4 groups were higher （P〈0.05 ） , and the levels of folic acid and Vit Bn were lower （P〈0.05 ） . Compared to simple hypertension group, the other hypertension groups had higher level of Hcy and hyperhomocysteinemia rate （P〈0.05 ） and lower levels of folic acid and Vit B12 （P〈0.05 ） . Compared to hypertension with CHD group, hypertension with DM group and hypertension with other disease group had higher level of Hcy （P〈0.05 ） and lower levels of folic acid and Vit B12 （P〈0.05 ） . There was no statistical significance of other comparisons among groups （P〉0.05 ） . Conclusions High level of Hcy, low level of Vit Bn and low levelof folic acid are risk factors for hypertension and its complications. Hypertension is associated with age, tobacco and alcohol abuses and BMI.
出处
《检验医学》
CAS
2017年第1期41-44,共4页
Laboratory Medicine
