摘要
目的探讨N5,10-亚甲基四氢叶酸还原酶(MTHFR)C677T位点突变与蒙古族高血压病患者之间的关系。方法采用Sequenom系统检测110例高血压病患者及115例健康对照组MTHFR基因多态性。结果蒙古族高血压人群MTHFR基因TT基因型频率及T等位基因频率(0.15,0.32)与正常人群(0.10,0.29)相比差异无显著性(P>0.05);单纯收缩压增高人群MTHFR基因型TT基因型及T等位基因频率(0.23,0.40)高于正常人群,差异有显著性(P<0.05)。结论MTHFR C677T位点TT基因型及T等位基因突变增加蒙古族人群单纯收缩压增高的危险性,可能是单纯收缩期高血压病的易感基因。
Objective To investigate the association between C667T point mutation of N5,10-methylene tetrahydrofolate reductase （MTHFR） and mongolian patients with hypertension. Methods Sequence system is used to test MTHFR genepolymorphism of 110 patients with hypertension, 115 healthy adults served as control. Results The frequencies of TT genotype（0. 15） and T allele （0.32）in mongolian patients with hypertension was of difference with those in control（0. 10 and 0.29 respectively, P〉0. 05）. Patients with isolated systolic high blood pressure had the frequency of TT genotype and T allele of 0.23 and 0.40 respectively, which are significantly higher than that of control（0.23 vs 0.10; 0.40 vs 0. 29, P〈0.05）. Conclusion TT genotype and T allele of MTHFR C677T increase the risk of isolated systolic high blood pressure, which may be a predisposing gene for hypertension disease in mongolian.
出处
《高血压杂志》
CSCD
北大核心
2006年第4期274-276,共3页
Chinese Journal of Hypertension
基金
内蒙古医学院重大课题资助
编号:NY2004ZD006
