摘要
目的探讨心肌酶谱与酒依赖患者成瘾严重程度的相关性。方法采用全自动生物化学分析仪对95例酒依赖患者(观察组)心肌酶谱,包括谷草转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CKMB)、羟丁酸脱氢酶(HBDH)的活性进行检测,并与同期46例体检健康者(对照组)进行比较。采用密西根酒精依赖调查表(MAST)评分对酒依赖患者的严重程度进行评估,采用Spearman相关分析对心肌酶谱评分与酒依赖患者成瘾严重程度的相关性进行分析。结果观察组患者血清AST、CK、CK-MB、HBDH水平显著高于对照组(P<0.01),而2组患者血清LDH水平比较差异无统计学意义(P>0.05)。MAST评分轻度15例,中度24例,较重35例,重度21例;MAST评分越高,血清AST、CK、CK-MB和HBDH水平也越高(P<0.01);Spearman相关分析结果显示,观察组患者血清AST、CK、CK-MB、HBDH水平与MAST评分呈正相关(r=0.746、0.813、0.523、0.701,P<0.01)。结论心肌酶谱与酒依赖患者的MAST评分密切相关,并且其水平与病情程度呈正相关。
Objective To investigate the correlation between myocardial enzyme spectrum and addiction severity degree in male patients with alcohol dependence. Methods The myocardial enzyme spectrum of 95 patients with alcohol dependence（ observation group） including aspartate aminotransferase（ AST）,lactate dehydrogenase（ LDH）,creatine kinase（ CK）,creatine kinase isoenzyme（ CK-MB） and the activity of hydroxybutyrat dehydrogenase（ HBDH） were detected by automatic biochemical analyzer. And 46 healthy people who underwent the physical examination were chosen as the control group. The addiction severity degree of patients were evaluated by Michigan altoholism screening test（ MAST） score,the correlation between addiction severity degree and myocardial enzyme spectrum of patients were analysed by Spearman correlation analysis. Results The serum AST,CK,CK-MB,HBDH levels of patients in observation group were significantly higher than those in the control group（ P〈0. 01）; there was no significant difference of LDH level of patients between the two groups（ P〉0. 05）. MAST score was mild in 15 cases,moderate in 24 cases,heavier in 35 cases,severe in 21 cases. The AST,CK,CK-MB and HBDH levels increased with the increase of the MAST scores（ P〈0. 01）. Spearman correlation analysis showed that the serum AST,CK,CK-MB and HBDH levels were positively correlated with MAST score（ r = 0. 746,0. 813,0. 523,0. 701,P〈0. 01）. Conclusion The myocardial enzyme spectrum is closely related to the MAST scores of the patients with alcohol dependence,and the levels of myocardial enzyme spectrum is positively correlated with the addiction severity degree.
出处
《新乡医学院学报》
CAS
2017年第1期56-58,共3页
Journal of Xinxiang Medical University
基金
河南省医学科技攻关计划项目(编号:301303109)
关键词
男性
酒依赖
心肌酶谱
成瘾
male
alcohol dependence
myocardial enzyme spectrum
addiction
