摘要
目的探讨磁共振弥散加权成像技术在肝癌介入治疗疗效评价中的应用价值。方法选取2013年2月至2015年10月本院收治的45例采取介入方法治疗的肝癌患者，回顾性分析所有患者的临床资料，并进行总结，所有患者均采用肝癌动脉灌注化疗栓塞治疗（TACE）作为介入治疗的方法，并在介入治疗前1天及治疗后1周进行常规MRI扫描及弥散加权成像扫描，利用软件测量出肿瘤组织、正常肝脏部位及脾脏的表观弥散系数（ADC），比较治疗后的效果。结果当b值为50s／mm^2、400s／mm^2和1000s／mm^2时，病灶的信号呈中高或高信号，介入治疗前肿瘤病灶的ADC为（0．87±0．14）×10^-3mm^2／s，治疗后的ADC值为（1．16±0．19）×10^-3mm^2／s，二者比较有显著性差异（P〈0．05）；介入治疗前正常肝脏组织的ADC为（0．90±0．10）×10^-3mm^2／s与治疗后的ADC值为（0．93±0．11）×10^-3mm^2／s比较无显著性差异（P〉0．05）；介入治疗前脾脏的ADC为（0．83±0，09）×10^-3mm^2／s与治疗疗后的ADC值为（0．84±0．08）×10^-3mm^2／s比较无显著性差异（P〉0．05）；当b值为50s／mm^2、400s／mm^2和1000s／mm^2时，治疗前患者的肿瘤体积为（190．2±54．09）cm^3，治疗后患者的肿瘤体积为（160．5±44．39）cm^3，肿瘤体积显著减少，且差异具有统计学意义（P〈0．05）。结论磁共振弥散加权成像技术在肝癌的介入治疗中的有较高的应用价值，介入治疗后肝癌病灶的ADC值显著升高，提示肝癌介入治疗后ADC值的改变能客观地反映介入治疗后肿瘤组织结构内部的变化，有助于介入治疗疗效的评价。
Objective To investigate the diffusion weighted MR imaging in the interventional treatment of liver cancer in the evalua- tion of efficacy. Methods from February 2013 to October 2015 45 cases taken interventional treatment of liver cancer patients admitted to our hospital, retrospectively analyzed the clinical data of all patients, and to sum up, all patients were treated with hepatocellular carcinoma arterial chemoembolization （TACE） as a method of intervention therapy and interventional treatment one day before and one week post treatment routine MRI scans and diffusion-weighted imaging scans, the use of software to measure the tumor tissue, normal liver and spleen, part of the apparent diffusion coefficient （AI）C）, Comparison of the effect of treatment. Results When the b value of 50s/mm^2, 400s/mm^2 and 1000s/mm^2, lesions showed high signal or high signal tumor lesion before interventional therapy ADC was （0.87±0.14）×10^-3mm^2/s, treatment After the ADC value （ 1.16 ± 0.19） ×10^-3 mm^2/s, there was a significant difference （ P〈 0. 05） between the two; ADC intervention before treatment was normal liver tissue （0. 90±0.10）×10^-3mm^2/s×10^-3mm2/no significant difference （P〈0.05） and after treatment ADC value （0.93±0.11） s; interventional treatment before spleen ADC was （0.83±0. 09）×10^-3 mm^2/s and therapy treatment After the ADC value （0.84±0. 08） ）〈 10-3 mm2/no significant difference （P〈0. 05 ） s; when b is 50s/mm^2 , 400 s/mm^2 and 1000s/mm^2 , pre-treatment of patients Tumor volume was （190.2 ±54.09）cm^3 , the tumor volume of patients after treatment （160.5±44.39）cm^3 , a significant reduction in tumor volume, and the difference was statistically significant （P〈0.05）. Conclusion diffusion weighted imaging has a higher value in the treatment of liver cancer in the intervention significantly increased ADC value of liver lesions after intervention, prompt change after interventional therapy ADC value can objectively reflect tumor after interventional treatment internal organizational structure changes, helping interventional therapy evaluation.
出处
《检验医学》
CAS
2016年第B09期85-86,共2页
Laboratory Medicine
