摘要
目的 探讨突触素（Syn） P63、甲状腺转录因子-1（TTF-1）对小细胞肺癌（SCLC）病理再 分型及临床治疗的价值.方法 回顾性分析2011年 1 月1日至2013年12月31日河北省人民医院经 病理组织学确诊为SCLC的 70例患者的临床资料,对病理组织标本进行HE染色,以免疫组织化学法 检测 Syn、P63、 TTF- 1的表达情况,三者联合检测区分出纯小细胞肺癌（ PSCLC）和复合性小细胞肺癌 （CSCLC）.所有患者应用EC化疗方案（卡铂＋ 依托泊苷）治疗,并进行随访,采用Kapkn-Meier进行生 存分析.结果 经病理检查后排除1 例低分化鳞癌.入组的69例 SCLC患者中,Syn阳性率为97. 1%（67/69）, P63阳性率为11.6%（8/69）, TTF-1阳性率为88. PSCLC 和CSCLC分别占79.7%（55/69）和 20.3%（14/ 69）.EC方案对 PSCLC 的治疗有效率明显高于CSCLCC60. 0%vs 14. 3%;）C2 = 9.330,P = 0.002h PSCLC 的中位总生存时间为 19.9 个月,CSCLC 为12.0个月,PSCLC 的预后总生存率显著优于CSCLC,差异具有统计学意义（ χ2=9. 579,P = 0.002）.结论Syn、P63和TTF-1联合检测有助于SCLC的病理再分型; EC方案对PSCLC的有效率优于CSCLC, PSCLC的预后 总生存率也优于CSCLC.
Objective To investigate the value of Syn, P63 and TTF-1 in pathological typing and clinical treatment of small cell lung cancer（SCLC） . Methods The clinical data of 70 patients with SCLC confirmed by histopathological examination between January 1st 2011 and December 31th 2013 in Hebei General Hospital were analyzed retrospectively. Pathological sections were subject to HE staining. Immunohistochemistry was used to detect the expression of synaptophysin （Syn）, P63 and thyroid transcription factor-1 （TTF-1） . Then the pathological sections were retyped to distinguish the pure small cell lung cancer （PSCLC） and combined small cell lung cancer （CSCLC） . All patients were treated by chemotherapy of EC scheme（CarboplatinH-Etoposide） . Patients were followed up, and survival analysis was performed by Kaplan-Meier. Results After pathological examination, one case of poorly differentiated squamous cell carcinoma was excluded. Among the included cases, the positive rates of Syn, P63 and TTF-1 were 97. 1 % （67/69） , 11. 6% （8/69） and 88. 4% （61/69） , respectively. PSCLC and CSCLC accounted for 79. 7%（55/69） and 20. 3%（14/69）, respectively. The effective rate of EC scheme in PSCLC was significantly higher than that in CSCLC （60. 0% vs 14. 3 % ; χ2 = 9. 330, P = 0.002）. The median overall survival durations in PSCLC and CSCLC were 19. 9 months and 12. 0 months, respectively. The overall survival in PSCLC was significantly higher than that in CSCLC （χ2 = 9.579, P = 0. 002） . Conclusions The pathological typing of SCLC can benefit from the combined detection of Syn, P63 and TTF-1. The effect of EC scheme on PSCLC is better than that on CSCLC. The prognosis of PSCLC is significantly better than that of CSCLC.
出处
《中华胸部外科电子杂志》
2016年第4期204-208,共5页
CHINESE JOURNAL OF THORACIC SURGERY：Electronic Edition
基金
河北省卫生计生委指令性计划课题(20150121)
